摘要
目的探讨尼麦角林治疗老年慢性脑血管功能不全的临床效果。方法采用随机数表法将本院神经内科2012年7月至2014年7月收治的162例老年慢性脑血管功能不全患者分为尼麦角林组和常规组,每组各81例。常规组患者采用常规治疗方法,尼麦角林组患者在常规治疗基础上加用尼麦角林。比较两组患者治疗的临床效果。结果治疗前,两组患者大脑中动脉、椎动脉的彩色多普勒超声检测指标[舒张期末流速(Vd)、收缩期峰流速(Vs)、阻力指数(RI)、搏动指数(PI)]比较差异均无显著性(P>0.05);治疗后12周,两组患者的Vd、Vs、RI、PI较组内治疗前明显好转,差异均具有显著性(P<0.05),且尼麦角林组患者的Vd、Vs、RI、PI优于常规组,差异具有显著性(P<0.05)。治疗前两组患者的简易精神状态检查量表(MMSE)评分比较差异无显著性(P>0.05);治疗后两组患者MMSE评分较治疗前均显著提高(P<0.05),且尼麦角林组患者的MMSE评分[(24.5±1.3)分]显著高于常规组[(22.9±1.5)分],差异具有显著性(P<0.05)。治疗后12周,尼麦角林组患者治疗总有效率(91.36%)高于常规组(76.54%),差异具有显著性(P<0.05)。结论尼麦角林可以改善老年慢性脑血管功能不全患者的临床症状及大脑血管血流情况,同时可以显著提高临床治疗效果。
Objective To investigate the clinical effect of nicergoline in treatment of elderly patients with chronic cerebrospinal venous insufficiency. Method Used random number table method to selected 162 cases of elderly patients with chronic cerebrovascular venous insufficiency from July 2012 to July 2014 in our hospital as research objects, they were divided into nicergoline group and routine group, 81 cases in each group. Routine group patients were treated with conventional methods, on the basis of conventional treatment, nicergoline group patients were treated with nicergoline. Clinical effects of the two groups were compared. Result Before treatment, the index [color Doppler ultrasound detection of vertebral artery and middle cerebral artery, the end diastolic velocity （Vd）, peak systolic velocity （Vs）, resistance index （RI）, pulsatility index （PI）] were not signiifcant different （P〉0.05）;12 weeks after treatment, Vd, Vs, RI, PI of the two groups patients were signiifcantly improved than before treatment, the difference was signiifcant （P 0.05）;after treatment, MMSE scores of the two groups patients were signiifcantly increased than before treatment （P 〈 0.05）, and MMSE scores of nicergoline group was （24.5±1.3） points, signiifcantly higher than routine group [（22.9±1.5） points], the difference was signiifcant （P〈0.05）. 12 weeks after treatment, total effective rate of nicergoline group was 91.36%, signiifcantly higher than routine group （76.54%）, the difference was signiifcant （P〈0.05）.＆nbsp;Conclusion Nicergoline can improve patients with elderly chronic cerebrospinal venous insufifciency clinical symptoms and brain blood lfows, and can signiifcantly improve the clinical treatment effect.
出处
《中国医学前沿杂志（电子版）》
2015年第3期134-137,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
尼麦角林
老年
慢性脑血管功能不全
临床疗效
Nicergoline
Elderly
Chronic cerebrospinal venous insufifciency
Clinical effect
