摘要
目的 观察中西医结合治疗对稳定型冠状动脉粥样硬化性心脏病（冠心病）患者左心室收缩功能的改善及对血压、心率等指标的影响.方法 纳入2013年1-10月就诊于首都医科大学附属北京安贞医院的慢性稳定型冠心病患者30例.根据配对原则分为西药常规治疗组和中西医结合治疗组,各15例.西药常规治疗组患者按照指南采用西药常规治疗;中西医结合治疗组在西药常规治疗组治疗方案的基础上加用活心丸,3丸/d,口服.治疗8周后,比较2组患者治疗前后左心室收缩功能与血压、心率等指标的变化情况.结果 西药常规治疗组收缩压、舒张压、心率、左心室射血分数（LVEF）、左心室短轴缩短分数（LVFS）治疗前后比较[（134±14） mmHg（1 mmHg =0.133 kPa）比（129±11） mmHg,（80±9）mmHg比（73±12） mmHg,（66±5）次/min比（65±9）次/min,（61±8）％比（62±5）％,（35±7）％比（36±10）％],差异无统计学意义（P＞0.05）.中西医结合治疗组收缩压、舒张压、心率、LVEF、LVFS治疗前后比较[（132±14） mmHg比（110±9）mmHg,（76±11）mmHg比（70±8）mmHg,（65±7）次/min比（60±5）次/min,（59±7）％比（65±10）％,（32±5）％比（37±8）％],差异均有统计学意义（均P＜0.05）;中西医结合治疗组的心率、收缩压比西药常规治疗组降低更明显,LVEF和LVFS比西药常规治疗组升高更明显,差异有统计学意义（P＜0.05）.结论 中西医结合治疗可能具有改善稳定型冠心病患者左心室收缩功能的作用.
Objective To observe the effect of integrated traditional Chinese and western medicine in improvement of left ventricular systolic function in patients with stable coronary artery disease.Methods Totally 30 cases of patients with coronary heart disease were enrolled and divided into integrated traditional Chinese and western medicine group （15 cases） and conventional western medicine group （15 cases）.The patients were given conventional western medicine according the guideline in conventional western medicine group,and were given Huoxin pills plus routine treatment in integrated traditional Chinese and western medicine group.After 8 weeks of treatment,the changes of blood pressure,heart rate,left ventricular ejection fraction （LVEF） and left ventricular fractional shortening （LVFS） were measured and compared between the two groups.Results Before and after treatment,the systolic pressure,diastolic pressure,heart rate,LVEF and LVFS were （134±13） mmHg and （129 ± 119） mmHg,（80 ±9） mmHg and （73 ± 12） mmHg,（66 ±5） times/min and （65 ±9） times/min,（61 ±8）％ and （62 ±5）％,（35 ±7）％ and （36 ± 10）％ in conventional western medicine group,（132 ± 14） mmHg and （110 ±9） mmHg,（76 ± 11） mmHg and （70 ±8）mmHg,（65 ±7） times/min and （60 ±5） times/min,（59 ± 7）％ and （65 ± 10）％,（32 ± 5）％ and （37 ± 8）％ in integrated traditional Chinese and western medicine group,respectively.The systolic pressure,diastolic pressure,heart rate,LVEF and LVFS were all statistically improved after treatment in integrated traditional Chinese and western medicine group （all P ＜ 0.05）;while only the diastolic blood pressure was significantly reduced after treatment in conventional western medicine group （P ＜ 0.05）,the other indicators were not statistically improved （all P ＞ 0.05）.The systolic pressure and heart rate were more reduced,the LVEF and LVFS were more increase in integrated traditional Chinese and western medicine group compared with conventional western medicine group （all P ＜ 0.05）.Conclusion Integrated traditional Chinese and western medicine may improve the left ventricular systolic function in patients with stable coronary artery disease.
出处
《中国医药》
2015年第5期619-622,共4页
China Medicine
关键词
稳定型冠心病
左心室收缩功能
中西医结合
Stable coronary artery disease
Left ventricular systolic function
Integrated traditional Chinese and western medicine
