摘要
目的探讨静脉高剂量使用左氧氟沙星治疗下呼吸道感染的临床有效性及安全性,为临床治疗提供参考依据。方法选取2010年1月-2013年3月收治的126例下呼吸道感染患者为研究对象,将其随机分为观察组和对照组各63例,观察组静脉滴注盐酸左氧氟沙星0.5g、每日1次,对照组静脉滴注盐酸左氧氟沙星0.2g、每日2次,治疗1~2周后观察将两组患者疗效、胸部X线摄片阴影好转率、细菌清除率及不良反应发生率进行比较。结果治疗总有效率观察组为93.65%,明显高于对照组的58.73%;观察组胸部X线摄片阴影的消失率为76.19%,高于对照组的39.68%;痰菌培养清除率为87.50%,高于对照组的60.00%;不良反应的发生率为7.94%,低于对照组的33.33%,以上结果差异均有统计学意义（P〈0.05）。结论静脉高剂量给予左氧氟沙星治疗下呼吸道感染疗效良好、安全性好、不良反应少,且在可耐受范围内,具有重要临床价值。
OBJECTIVE To evaluate the clinical efficacy and safety of use of high doses of intravenous levofloxacin in the treatment of lower respiratory tract infections,so as to provide clinical references for clinical treatment.METHODS From Jan.2010 to Mar.2013,altogether 126 cases of patients with respiratory tract infections admitted in the hospital were selected as the study objects and they were randomly divided into observation group and control group with 63 patients in each group.The observation group was treated with intravenous infusion of levofloxacin hydrochloride with 0.5g/time/d.While the control group received intravenous infusion of levofloxacin hydrochloride with 0.2g/times and 2times/d.The clinical efficacy,the shadow improvement rate of chest X-ray images,the clearance rate of bacteria and the occurrence rate of adverse reactions were compared 1to 2weeks after treatments.RESULTS The total effective rate in the observation group was 84.12%,which was significantly higher than the control group with the rate of 58.73%.The shadow fade rate of chest X-ray image was 76.19%in the observation group and it was higher than the control group of 39.68%.The clearance rate of bacteria was87.50%in the observation group,which was higher than that of the control group of 60.00%.The incidence rate of adverse reactions was 7.94% in the observation group and it was lower than that of the control group of33.33%.The differences above were significant（P〈0.05）.CONCLUSIONIntravenous infusion of levofloxacin owns obvious efficacy,good safety and less adverse reactions for the treatment of lower respiratory tract infections and within tolerable range,it has important clinical value.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第8期1753-1754,1760,共3页
Chinese Journal of Nosocomiology
基金
河南省卫生厅中青年医师扶持基金项目(201001018)
关键词
左氧氟沙星
下呼吸道感染
有效性
Levofloxacin
Lower respiratory tract infections
Effectiveness
