摘要
利奈唑胺对革兰阳性（G＋）菌抗菌作用强，具有较好的药代动力学特征，组织穿透性好，血浆或血清中＞50%利奈唑胺可以穿透到感染组织，在不同感染组织针对不同病原菌PK/PD参数有所不同，中国人群利奈唑胺敏感菌最小抑菌浓度（MIC）为0.5~2μg/mL，对特定病原菌具有抗生素后效应，是治疗G＋菌感染的糖肽类多重耐药的最后防线。本文就利奈唑胺针对G＋菌感染治疗的组织穿透性及在感染组织中的药效动力学作一综述，为临床合理选用利奈唑胺提供参考。
Linezolid has strong antibacterial activities for G＋infection and perfect pharmacokinetics and tissue penetration,more than 50%plasma（or serum）concentration of linezolid was detected in the infected tissues.Different PK/PD parameters was found according to different pathogens and different infected tissues.The MIC value of linezolid for susceptible bacteria was 0.5-2μg/mL.The post-antibiotic effect of linezolid was found in some specific bacteria.Linezolid can be used as the most solid barriers in the treatment of multiresistant G＋infection.The tissue penetration and pharmacodynamics characteristics of linezolid in the treatment of G＋infection is summarized,which can help healthy providers decide how to use linezolid in the treament of G＋infections.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2015年第3期349-355,共7页
Chinese Journal of Clinical Pharmacology and Therapeutics
