摘要
目的：观察血必净注射液对脓毒症患者心肌损伤的保护作用。方法：选取2013年1月～2014年6月在我院ICU住院的脓毒症患者30例，检测外周血血清肌钙蛋白I（ cTn I）和N－末端脑钠肽前体（ NT－proBNP）的浓度，给予血必净注射液50ml静脉微泵，1天3次，72小时后复查cTn I、NT－proBNP。同时选取同期住院的健康体检者30例为非脓毒症对照组，在入院的24小时内检测外周血血清cTn I和NT－proBNP的浓度。结果：脓毒症组血清cTn I和NT－proBNP浓度与非脓毒症组比较均明显升高（P＜0．01）；血清cTn I浓度、NT－proBNP浓度与APACHEⅡ评分之间均呈正相关。30例脓毒症患者中有10例死亡，其血清cTn I、NT－proBNP浓度均较生存病例高。结论：脓毒症患者存在心肌抑制，其cTn I、NT－proBNP水平升高，与预后有较好的相关性。血必净注射液能改善脓毒症患者的心肌损伤。
Objective：To investigate the protective effect of Xuebijing injection on myocardiac injury in patients with sepsis.Methods：30 sepsis patients with APACHEⅡscores over 12 and 20 normal controls were involved in the study.50 ml Xuebijing was administered by intravenous drip once every 8hours in the Xuebijing-treated group.Before treatment and 72 hours after treatment,the venous blood of the Xuebijing-treated group were collected.The cTn I and NT-proBNP levels in serum were detected.the correlations among the cTn I, NT-proBNP and APACHEⅡscore were investigated.Results：In the patients with sepsis, the average level of cTn I and NT-proBNP in serum was significantly higher than the control group （ P 〈0101） .In the patients with sepsis, there was a positive correlation between the levels of cTn I and the APACHE Ⅱscore （ r =0.413, P 〈0.05） , and the NT-proBNP levels were positively correlated with the APACHEⅡscore （r =0.836, P =0.000）.Among 30 patients with sepsis, 10 patients were dead, the cTn I and NT-proBNP levels in the 10 patients were higher than that of the survivors.Conclusion：The cTn I and NT-proBNP levels are increased in the serum of the patients with sepsis.Xuebijing injection improves myocardiac injury in patients with sepsis .
出处
《中国伤残医学》
2015年第7期11-13,共3页
Chinese Journal of Trauma and Disability Medicine
关键词
脓毒症
心肌损伤
血必净注射液
Protective effect
Xuebijing injection
Myocardiac injury
