摘要
目的:探讨乌司他汀治疗多脏器功能衰竭患者的临床疗效。方法:选取2011年1月—2013年3月新疆医科大学第一附属医院(以下简称"我院")门诊收治的96例多脏器功能衰竭患者作为研究对象,将患者随机分为研究组与对照组,每组48例。对照组患者给予常规治疗,研究组患者在常规治疗基础上给予乌司他汀治疗。结果:经治疗后两组患者白细胞计数、心率、呼吸频率、白细胞介素6和肿瘤坏死因子α水平和尿素氮、肌酐浓度差异均有统计学意义(P<0.05),但两组患者均未见明显不良反应。结论:乌司他汀治疗多脏器功能衰竭疗效明显,值得在临床中进一步推广应用。
OBJECTIVE ： To evaluate the efficacy and safety of ulinastatin for multiple organ failure. METHODS ： 96 patients with multiple organ failure seen in Xinjiang Medical University First Affiliated Hospital （hereinafter referred to as ＂our hospital＂） from January 2011 to March 2013 were randomized to either trial group or control group of 48 cases each. The control group was assigned to receive routine therapy while the trial group to receive add-on ulinastatin. RESULTS： After treatment, statistically significant differences were noted between the two groups in white blood count, heart rate, breathing rate, interleukin, tumor necrosis factor, urea nitrogen and creatinine concentration （P 〈 0. 05）. No significant averse drug reactions were noted in either group. CONCLUSIONS ： Ulinastatin was proved to be of remarkable efficacy for multiple organ failure which thus is worthy of further promotion and application in clinical use.
出处
《中国医院用药评价与分析》
2015年第2期159-161,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
多脏器功能衰竭
乌司他汀
炎性介质
Multiple organ failure
Ulinastatin
Inflammatory mediators
