摘要
背景:研究证实姜黄素具有抗炎抗氧化抗凋亡作用。目的:综合阐述姜黄素保护关节软骨及抑制骨关节炎等方面的机制和作用。方法:作者检索1973至2014年Pub Med、Embase、Elseveir数据库文献。检索词为"Osteoarthritis,curcumin,chondrocyte,articular cartilage",按照事先制定的标准逐一评价纳入研究的文献,提取有效资料进行综合分析。结果与结论:姜黄素可通过抑制氧化作用酶,清除自由基,完成抗氧化作用,从而防止骨关节炎的发生和进展。姜黄素抑制基质金属蛋白酶的对软骨基质的消耗,增加Ⅱ型胶原的产生。姜黄素通过抑制胞浆型磷脂酶A2,环氧化酶2,脂氧合酶5,从而完成抗炎反应。姜黄素抑制白细胞介素1β导致的线粒体肿胀和凋亡,完成抗凋亡作用。临床研究提示,姜黄素或者其衍生物骨关节炎患者膝关节功能、关节疼痛等均有改善。高浓度姜黄素对体外培养的细胞和组织有毒性作用。
BACKGROUND：Curcumin is proved to possess anti-inflammatory, antioxidant and anti-apoptotic roles. OBJECTIVE： To summarize and discuss the mechanisms and effects of curcumin used for the treatment of osteoarthritis METHODS： PubMed, Embase, Elseveir databases were retrieved for relevant articles published from 1973 to 2014, with the key words of “osteoarthritis, curcumin, chondrocyte, articular cartilage” in English. After the quality of the included studies was evaluated, valid data were extracted and analyzed. RESULTS AND CONCLUSION：Curcumin prevents the occurrence and development osteoarthritis by inhibiting oxidative enzyme and scavenging free radicals. Curcumin increases production of colagen type 2 through suppressing the reduction of cartilage matrix by matrix metaloproteinases. Anti-inflammatory reaction of curcumin can be achieved by inhibiting cytosolic phospholipase A2, cyclooxygenase-2, and 5-lipoxygenase. Curcumin inhibits interleukin-1β-induced apoptosis of chondrocytes and mitochondrial sweling. Results from clinical trials suggest that curcumin or its derivatives can reduce joint pain and improve the function of knee joints in patients with osteoarthritis. High-concentration curcuminin vitro have been demonstrated toxic effects.
出处
《中国组织工程研究》
CAS
北大核心
2015年第2期277-282,共6页
Chinese Journal of Tissue Engineering Research
