摘要
目的研究经口内镜下肌切开术（POEM）治疗贲门失弛缓症（EA）气体相关并发症的发生情况及发生率，并探讨其危险因素。方法回顾性分析我院2011年8月至2013年11月216例接受POEM治疗的EA患者的临床资料，并对气体相关并发症的可能潜在危险因素进行单因素分析和多因素回归分析。结果本组患者气体相关并发症发生率为10．2％（22／216），单因素分析显示，S形食管、隧道入口采用单纯纵形切口法、隧道宽度≤3cm、肌切开深度、操作时间为气体相关并发症的危险因素（P〈0．05）。多因素分析表明，隧道人口采用单纯纵形切口法、隧道宽度≤3cm、S形食管为该并发症发生危险因素（P〈0．05）。结论隧道入口采用单纯纵形切口法、隧道宽度≤3cm、S形食管是POEM治疗EA气体相关并发症的独立危险因素，而肌切开深度并非该并发症发生的危险因素。
Objective To investigate the risk factors and incidence of gas-related complications in peroral endoscopic myotomy for easophageal achalasia. Methods Clinical data of 216 patients with achalasia treated by peroral endoscopic myotomy from August 2011 to November 2013 were collected. Potential risk factors for gas-related complications were analyzed by univariate and multivariate analysis. Results The incidence of gas-related complications was 10. 2% （22/216）. Univariate analysis showed risk factors for complications were Sigmoid type esophagus, simple longitudinal incision for tunnel entry, tunnel width ≤3 cm, degree of myotomy, and operation time（P 〈 0. 05）, while muhivariate analysis showed the risk factors were Sigmoid type esophagus, simple longitudinal incision for tunnel entry, and tunnel width ≤3 cm（P 〈 0.05）. Conclusion Simple longitudinal incision for tunnel entry, tunnel widths≤3 cm and sigmoid type esophagus are risk factors of gas-related complications in POEM, while myotomy depth is not.
出处
《中华消化内镜杂志》
北大核心
2015年第1期10-13,共4页
Chinese Journal of Digestive Endoscopy
基金
2012年国家临床重点专科建设项目[卫办医政函（2012）650号]
志谢 研究的统计学分析得到了中南大学公共卫生学院统计学教研室颜艳教授的大力帮助,在此深表感谢
关键词
食管失弛症
手术中并发症
危险因素
经口内镜下肌切开术
Esophageal achalasia
Intraoperative complications
Risk factors
Peroral endoscopic myotomy
