摘要
目的:研究参元益气活血胶囊联合早期冠脉介入对不稳定型心绞痛患者近期生活质量的影响。方法:78例不稳定型心绞痛患者随机分为治疗组和对照组,各39例,冠状动脉造影后行早期冠状动脉介入治疗(PCI)术,术前对照组给予常规西药治疗,治疗组给予常规西药治疗加参元益气活血胶囊,每次3粒,每日3次,疗程30天。治疗前后对两组患者生活质量进行评分,判定心绞痛、心电图及中医主症疗效。结果:与治疗前相比,两组患者治疗后躯体活动受限程度、心绞痛稳定状态、心绞痛发作情况、治疗满意程度计分均明显升高(P<0.05);与对照组比较,参元益气活血胶囊治疗组治疗后心绞痛发作频率、持续时间以及心悸、乏力、气短症状均明显改善(P<0.05),治疗组心绞痛稳定状态、心绞痛发作情况、治疗满意程度计分均明显升高(P<0.05)。结论:参元益气活血胶囊联合早期PCI治疗可以提高不稳定型心绞痛患者的近期生活质量和中医主症。
This study was aimed to investigate the effects of Shen-Y uan Y i-Qi Huo-Xue （SYYQHX） capsule com-bined with early percutaneous coronary intervention （PCI） on near-term quality of life （QOL） in unstable angina （UA） patients. Seventy-eight patients diagnosed with UA were selected and randomly divided into the treatment group and control group, with 39 patients in each group. Early PCI was undergone after coronary angiography. Before PCI, the control group was given routine western medication. The treatment group was given routine western medication plus SYYQHX capsule, three pills once, three times daily. The treatment lasted for 30 days. The QOL scores were evalu-ated among patients from both groups before and after treatment in order to determine the efficacy on angina, electro-cardiogram （ECG） and traditional Chinese medicine （TCM） main symptom. The results showed that compared to pre-treatment, the scores of physical limitation （PL）, angina stability （AS）, angina frequency （AF）, and treatment satisfac-tion （ TS ） were significantly increased after treatment （ P 〈 0 . 05 ） . Compared with the control group , after treat-ment with SYYQHX capsule, the AF, duration time and symptoms of palpitation, fatigue and shortness of breath were obviously improved （P〈 0.05）. The scores of AS, AF and TS in the treatment group were significantly increased （P 〈 0.05）. It was concluded that SYYQHX capsule combined with early PCI can improve the near-term QOL and TCM main symptoms among UA patients.
出处
《世界科学技术-中医药现代化》
北大核心
2014年第12期2593-2597,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委面上项目(81273741):益气逐瘀法干预不稳定型心绞痛择期介入治疗围手术期心肌保护研究
负责人:刘红旭
北京市科委首都临床特色应用专项(Z131107002213152):参元益气活血胶囊干预不稳定心绞痛择期PCI围手术期心肌损伤的临床研究
负责人:褚福永
教育部高等学校博士学科点新教师类专项基金(20131107120016):益气逐瘀法调控mi RNA-24干预缺血心肌细胞凋亡及其机制研究
负责人:褚福永
首都医科大学基础临床合作项目(13JL86):益气逐瘀法调控NF-κB炎症反应通路干预围手术期心肌损伤的机理研究
负责人:褚福永
关键词
参元益气活血胶囊
不稳定型心绞痛
冠脉介入术
生活质量
Shen-Y uan Y i-Qi Huo-Xue capsule
unstable angina
percutaneous coronary intervention
quality of life
