摘要
目的探讨动脉硬化闭塞症膝下动脉腔内治疗术后应用盐酸沙格雷酯后续治疗的疗效及安全性。方法选择我院2010年4月至2013年1月收治的100例采用膝下动脉腔内治疗成功的动脉硬化闭塞症患者作为研究对象,按术后治疗方案分为实验组和对照组各50例,对照组采用阿司匹林联合硫酸氢氯吡格雷治疗,实验组患者在此基础上加用盐酸沙格雷酯治疗,比较两组患者术前、术后1个月、3个月和6个月的踝肱指数(ABI)、血管通畅率以及截肢、静息痛和间歇性跛行情况。结果实验组患者在术后6个月时间歇性跛行发生率远低于对照组,差异有统计学意义(P<0.05),但两组患者在其他时段的截肢、静息痛、间歇性跛行发生率比较差异均无统计学意义(P>0.05)。手术后两组患者ABI指数较术前均有较大改善,术后1个月、3个月和6个月与术前比较差异均有统计学意义(P<0.05),但两组患者在各时段的ABI指数和血管通畅率比较差异均无统计学意义(P>0.05)。结论盐酸沙格雷酯可在一定程度上降低动脉硬化闭塞症膝下动脉腔内治疗术后间歇性跛行的发生风险,安全性良好,对改善预后有着积极的促进作用。
Objective To evaluate the efficacy and safety of hydrochloric sarpogrelate in follow-up treatment of percutaneous transluminal angioplasty in infrapopliteal arteriosclerotic occlusive disease.Methods One hundred patients from April 2010 to February 2013 in our hospital were chosen as the study subjects,which were divided into experimental group and control group.The control group（n=50） was treated with aspirin and clopidogrel bisulfate,and the experimental group（n=50） was treated with hydrochloric sarpogrelate on the basis of control group.The ankle brachial index（ABI）,vascular patency and amputation,rest pain and intermittent claudication were compared before surgery,one month,three months,and six months after surgery.Results The incidence of intermittent claudication in the experimental group was significantly lower than that in the control group six months after surgery（P〈0.05）,but there was no statistically significant difference between the two groups in rest pain,incidence of intermittent claudication at other time points（P〉0.05）.ABI index was significantly improved in the two groups 1 month,3 months,6months after surgery,compared with that before surgery（P〈0.05）.There was no statistically significant difference between the two groups at the same time points in ABI index and vascular patency rate（P〉0.05）.Conclusion Hydrochloric sarpogrelate could reduce the risk of intermittent claudication on patents with percutaneous transluminal angioplasty in infrapopliteal arteriosclerotic occlusive disease,with good safety.
出处
《海南医学》
CAS
2015年第2期172-174,共3页
Hainan Medical Journal
基金
海南省自然科学基金(编号:30855)
关键词
动脉硬化闭塞症
盐酸沙格雷酯
腔内治疗术
疗效
安全性
Infrapopliteal arteriosclerotic occlusive disease
Hydrochloric sarpogrelate
Transluminal angioplasty
Efficacy
Safety
