摘要
目的探讨星状神经节阻滞（SGB）对肺癌患者免疫功能的影响。方法选取2013年1~6月在本院行胸腔镜肺叶切除术治疗的40例非小细胞肺癌患者,按照随机数字表法将其分为Ⅰ组和Ⅱ组各20例。Ⅰ组患者行右侧SGB,Ⅱ组不行SGB。检测两组肺癌患者术前（T0）、术毕（T1）、术后1 d（T2）、术后3 d（T3）外周血清中的转化生长因子-β（TGF-β）、白细胞介素-4（IL-4）、白细胞介素-6（IL-6）的表达。结果Ⅱ组患者血清TGF-β、IL-4、IL-6在T1、T2、T3明显升高,与Ⅰ组比较其差异有统计学意义（P ＜ 0.05）。结论 SGB能缓解肺癌患者的近期免疫抑制。
Objective]To explore the effect of stellate ganglion block（SGB）on immune function of pa-tients with lung cancer.[Methods]A total of 40 patients with non small cell lung cancer undergoing thoraco-scopic lobectomy in our hospital from January 2013 to June 2013 were chosen and randomly divided into groupⅠ and group Ⅱ with 20 patients in each group.Group Ⅰ underwent SGB,while group Ⅱ did not underwent SGB.The serum levels of transforming growth factor beta（TGF-beta）,interleukin-4（IL-4）and interleukin-6 （IL-6）in peripheral blood of two groups before（T0 ）,at the end （T1 ）,1d（T2 ）and 3d after operation（T3 ） were detected.[Results]Serum levels of TGF-beta,IL-4 and IL-6 at T1 ,T2 and T3 in group Ⅱ were obvious-ly increased,and there were significant differences between group Ⅱ and group Ⅰ（P 〈 0.05）.[Conclusion]SGB can alleviate the short-term immunosuppression in patients with lung cancer.
出处
《医学临床研究》
CAS
2014年第12期2321-2322,共2页
Journal of Clinical Research
基金
湖南省科技厅科技计划一般项目（编号2013SK3267）
