摘要
目的 探讨正常妊娠妇女血脂特异性参考区间评价妊娠期糖尿病（GDM）患者血脂的价值.方法 选择2011年10月～2013年10月来院的GDM孕妇95例（GDM组）和同期健康孕妇100例作为对照组,妊娠32～34周,清晨空腹采肘静脉血3ml,常规离心取血清,采用全自动生化分析仪检测血清中总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL）以及低密度脂蛋白胆固醇（LDL）.建立正常妊娠特异性血脂参考区间,并对GDM孕妇血脂状况进行评价.结果 与对照组比较,GDM组孕妇血脂HDL和LDL水平显著升高（P＜0.05）.以正常妊娠特异性血脂参考区间为标准：GDM组孕妇低水平和高水平HDL新生儿体质量显著增加（P＜0.05）,而高水平LDL新生儿体质量显著减少（P＜0.05）.新生儿体质量与母体HDL间无相关性,而与LDL间存在显著的负相关性（P＜0.05）.结论 采用正常妊娠妇女血脂特异性参考区间评价GDM孕妇血脂水平具有重要的临床价值.
Objective To explore the value of normal pregnancy lipid reference range on evaluating lipid of patients with GDM. Methods 95 pregnant women with GDM were divided into GDM group and 100 cases of healthy pregnant women were selected as control group. Three milliters of venous blood were taken at 32 to 34 weeks gestation. The ser- um was taken by conventional centrifugal. The levels of total cholesterol （TC）, triglyceride （TG）, high density lipopro- tein cholesterol （HDL） and low density lipoprotein cholesterol （LDL） in serum were detected using automatic biochemical analyzer. The pregnancy-specific reference range of lipid was established and the lipid profile of pregnant woman with GDM was evaluated. Results Compared with control group, the levels of HDL and I.DL in body lipid of pregnant woman with GDM were significantly increased （P〈0.05）. According to the normal pregnancy-specific reference range of lipid, the weight of newborn increased significantly in GDM group with low and high levels of HDL（P〈0. 05）, while the weight of newborn decreased significantly in GDM group with high levels of LDL（P〈0.05）. There was no correlation between newborn weight and maternal HDL, but there was a a significant negative correlation between newborn weight and maternal I.DL. Conclusion Using lipid-specific reference range of normal pregnant women to evaluate the lipid levels of pregnant woman with GDM has an important value.
出处
《西部医学》
2015年第1期97-98,101,共3页
Medical Journal of West China
关键词
糖尿病
妊娠
血脂
Diabetes
Pregnancy
Lipids
