摘要
目的:本研究旨在探讨趋化性细胞因子及一氧化氮水平变化与呼吸道感染的关系。方法:选取2012年8月至2013年8月期间我院呼吸内科收治的细菌性呼吸道感染患者40例作为观察组,同期健康研究对象30例作为观察组,比较观察组在入院时、入院后第3天、入院后第7天、出院时的细胞因子(TNF-α)、一氧化氮(NO)及白细胞介素(IL-6、IL-17、IL-10)水平差异,并分别同对照组进行比较。结果:观察组患者在入院时、入院后第3天、入院后第7天、出院时的TNF-α、NO、IL-6、IL-17、IL-10水平比较差异均具有统计学意义(F=10.849,P<0.05),随着治疗时间的延长,患者呼吸道感染症状逐渐好转直至出院,可以发现上述各指标均随时间的延长而逐渐下降;观察组入院后第3天、入院后第7天、出院时的TNF-α、NO、IL-6、IL-17、IL-10水平分别与入院时比较差异均具有统计学意义(P<0.05)。结论:通过测定呼吸道感染患者的细胞因子水平及NO水平,可以判断患者的病情转归程度。
Objective：This study aims to explore the relationship between respiratory tract of chemotactic cytokines and nitric oxide levels of infection.Methods：40 cases of patients as the observation group during August 2012 to August 2013 were selected in our hospital respiratory department of internal medicine were respiratory tract infection , healthy subjects 30 cases as the observation group,the observation group at the time of admission ,admission after 3 d,the 7 d after be admitted to hospital ,hospital of cytokines （TNF-α）,nitric oxide （NO） and interleukin （IL-6,IL-17,IL-10） level difference,and were compared with the control groups Results：Patients in the observation group at the time of admission ,admission after 3 d,compared with 7 d after admission,discharge of TNF-α,NO,IL-6,IL-17,IL-10 level differences were statistically significant （F=10.849,P〈0.05）,with the extension of treatment time,symptoms gradually improved until the patients with respiratory tract infection , can be found in the above indexes all time is gradually decreased;the observation group the 3 d after be admitted to hospital ,the 7 d after be admitted to hospital discharge ,TNF-α, NO,IL-6,IL-17,IL-10 levels were compared with admission differences were statistically significant Conclusion： By measuring the levels of cytokines and NO levels in patients withrespiratory tract infection ,can judge the prognosis of patients.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2014年第12期1676-1678,共3页
Chinese Journal of Immunology
