摘要
目的:探讨CA125联合中性粒细胞和淋巴细胞比值对卵巢癌诊断及预后判断的临床意义。方法:检测152例卵巢癌患者外周血CA125及血细胞计数,对比CA125水平及中性粒细胞与淋巴细胞比值(NLR)与健康体检者及卵巢良性疾病患者间的差异,评估二者及二者联合(联合标志物)在诊断卵巢癌方面的敏感性和特异性,并分析检测指标与卵巢癌患者临床特征的相关性。结果:卵巢癌患者的CA125水平及NLR值明显升高,与对照组及良性肿瘤组相比,差异均具有统计学意义(P<0.05);在敏感性上CA125最为显著,但在特异性上NLR及联合标记物要比CA125高;联合标志物与疾病的疗效及预后密切相关(r=0.683,P<0.01)。结论:CA125联合中性粒细胞和淋巴细胞比值测定是卵巢癌诊断的敏感指标,且具有更高的特异性,在对卵巢癌的诊断、病情评估及预后判断方面具有指导意义。
Objective：To investigate the clinical significance of CA 125 and neutrophil-to-lymphocyte in the diagnosis and prognosis of ovarian cancer.Methods：CA125 levels and blood cell counts in peripheral blood of 152 cases of ovarian cancer patients were detected and were compared with those of healthy and benign ovarian diseases among patients .Sensitivity and specificity of the two markers in the diagnosis of ovarian cancer were assessed and the correlation between the combined marker and clinical characteristics of patients with ovarian cancer were analyzed.Results： The level of CA125 and NLR in patients with ovarian cancer was significantly higher,compared with the control group and benign tumor group ,the differences were statistically significant （P〈0.05）;the sensitivity of NLR and combined markers were higher than CA 125 ,but the specificity of CA 125 was the most significant;the combined marker was closely related to the curative effect and prognosis of disease （r=0.683,P〈0.01）.Conclusion： Determination of CA125 combined with neutrophil-to-lymphocyte ratio is a sensitive index for the diagnosis of ovarian cancer and has guiding significance in severity assessment and prognosis of ovarian cancer.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2014年第12期1670-1671,1675,共3页
Chinese Journal of Immunology
基金
吉林省科技厅重点实验室项目(20122113)资助
