摘要
目的探讨在心功能正常情况下不稳定型心绞痛(unstable angina pectoris,UAP)与稳定型心绞痛(stable angina pectoris,SAP)患者血浆N-末端脑钠肽前体(NT-proBNP)浓度的差异及UAP患者血浆NT-proBNP浓度与肌钙蛋白I(cTnI)的相关性及其临床意义。方法选择住院冠心病心绞痛患者116例,其中SAP 54例,UAP组62例,UAP组中cTnI阳性者32例,cTnI阴性者30例,正常对照组35例,测定每位患者的血浆NT-proBNP、cTnI水平,比较不同组别NT-proBNP浓度及分析UAP患者NT-proBNP与cTnI的关系。结果 UAP患者血浆NT-proBNP浓度[146.55(53.65,772.55)pg/ml]高于SAP组[47.50(19.23,87.35)pg/ml]和对照组[33.38(14.07,66.60)pg/ml],差异有统计学意义(P<0.01),SAP组血浆NT-proBNP浓度与对照组比较,差异无统计学意义(P>0.05);UAP患者中cTnI阳性组血浆NT-proBNP浓度[646.86(127.85,1 181.63)pg/ml]高于cTnI阴性组[91.50(26.54,145.83)pg/ml],差异有统计学意义(P<0.01),UAP患者血浆NT-proBNP浓度与cTnI浓度呈正相关(r=0.57,P<0.05)。结论 UAP患者血浆NT-proBNP浓度增高,并与cTnI浓度呈正相关;心肌缺血是NT-proBNP释放的重要刺激因素之一,NT-proBNP与心肌缺血的严重程度有关;测定NT-proBNP有利于发现心功能正常但处于高风险的患者,使患者能得到早期干预,降低心血管事件发生的风险。
Objective To investigate the clinical significances of plasma level of N-terminal ProB-type natriureticpeptide（NT-proBNP） between unstable angina pectoris（UAP） and stable angina pectoris（SAP） and correlation betweenplasma cardiac troponin I（cTnI） and NT-proBNP in patients with UAP. Methods 116 patients with angina pectoriswere enrolled in this study, including 54 SAP, 62 UAP. 62 UAP patients were divided into cTnI（＋） group（n= 32） and30 cTnI（-） group（n= 30）, and 30 healthy persons were selected as control. The plasma level of NT-proBNP and cTnI ofall cases were measured and compared in the three groups and the correlation between cTnI and NT-proBNP in UAP pa-tients with cTnI（＋） were analyzed. Results Plasma levels of NT-proBNP were 146. 55（53. 65,772. 55） pg/ ml, 47. 50（19. 23, 87. 35）pg/ ml, 33. 38（14. 07, 66. 60）pg/ ml in the patients with UAP, SAP and control group respectively, thelevel of NT-proBNP in UAP group was significantly higher than that in SAP or control group（P〈0. 01）; there were no sig-nificant difference in NT-proBNP level between SAP and control group（P〉 0. 05）. Plasma levels of NT-proBNP were646. 86（127. 85, 1181. 63） pg/ ml, 91. 50（26. 54, 45. 83）pg/ ml in cTnI（＋） and cTnI（-） group respectively, the plas-ma level of NT-proBNP in the UAP group whose cTnI（＋）was significantly higher than those UAP patients whose cTnI（-）（P〈0. 01）,NT-proBNP level were positively correlated with cTnI in UAP（r= 0. 57,P〈0. 05）. Conclusions The plas-ma level of NT-ProBNP in UAP is increased and it positively correlated with cTnI. All of the patients with coronary heartdisease（CHD） should measure the plasma NT-proBNP to find out the patients at the high risk while whose heart function isnormal, and further to receive the early intervention, and reduce the incidence of cardiovascular risk.
出处
《实用老年医学》
CAS
2014年第12期1030-1032,1035,共4页
Practical Geriatrics
关键词
N-末端脑钠肽前体
肌钙蛋白-I
不稳定型心绞痛
稳定型心绞痛
N-terminal ProB-type natriuretic peptide
cardiac troponin I
unstable angina pectoris
stable angina pectoris
