摘要
目的:探讨WWOX、Bcl-2在非小细胞肺癌中的表达、与临床病理特征的关系及临床意义。方法:采用免疫组化SP法检测58例非小细胞肺癌(NSCLC)组织及20例相应癌旁正常肺组织中WWOX、Bcl-2的表达。结果:WWOX蛋白阳性表达率在NSCLC组织中明显低于癌旁正常肺组织;Bcl-2蛋白阳性表达率在NSCLC组织中明显高于癌旁正常肺组织;WWOX的低表达与NSCLC的临床分期、分化程度、淋巴结转移有关(P<0.05);Bcl-2的高表达与NSCLC的临床分期、分化程度、淋巴结转移有关(P<0.05);WWOX、Bcl-2在NSCLC组织的表达存在负相关(P<0.01),相关系数rs=-0.309。结论:WWOX的低表达、Bcl-2的高表达与NSCLC的发生、发展有关。二者在NSCLC的发生发展中可能起着拮抗作用。
Objective：To study the expression of WW domain-containing oxidoreductase（WWOX）and B-cell lymphoma/leukemia-2（Bcl-2）in non-small cell lung cancer（NSCLC）and their clinical significance.Methods：The expression of WWOX and Bcl-2were detected by immunohistochemical SP method in 58 cases non-small cell lung cancer tissue and 20 cases normal lung cancer tissue.Results：The positive expression rate of WWOX in NSCLC was lower than in normal lung tissue.The positive expression rate of Bcl-2in NSCLC was higher than in normal lung tissue.WWOX low expression was related to TNM stage,differentiation degree,lymph node metastasis（P〈0.05）.Bcl-2high expression was related to TNM stage,differentiation degree,and lymph node metastasis（P〈0.05）.The negative correlation was found between the expression of WWOX and Bcl-2（P〈0.01,correlation coefficient rs=-0.309）.Conclusion：WWOX low expression and Bcl-2high expression may play an important role in the oncogenesis and development of NSCLC.The both play antagonist role in the development of NSCLC.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2014年第6期914-916,921,共4页
Medical Journal of Wuhan University
