摘要
目的探讨类风湿关节炎(RA)的发病特点。方法收集RA患者188例,对患者进行为期12个月的调查,以每2周作为1个观测点,共设24个观测点。对每个观测点内就诊的患者检测C反应蛋白(CRP),观察28个关节肿胀关节数(TJC28)、压痛关节数(SJC28),用于计算28个关节疾病活动性得分(DAS28),同时进行中医辨证分型及收集气象因素资料,采用双变量线性相关分析对气象因素(温度、气压、相对湿度、风速)与DAS28进行相关分析。结果 188例RA患者中以寒湿痹阻型最多,共71例占37.8%,且多集中在冬季,各季节分布差异有统计学意义(P<0.05)。气象因素中温度、风速均与DAS28呈负相关(P<0.01)。结果寒湿痹阻为RA主要证候类型,且主要分布在冬季,温度和风速越低则RA疾病活动度越高。
Objective To explore the features of rheumatoid arthritis （RA） onset. Methods Totally 188 RA patients were selected and a 12-month investigation was made. Two weeks were taken as one observation point and 24 observation points were set up. The C-reactive protein （CRP） was detected at each observation point. The tender joint count （TJC28） and swollen joint count （SJC28） was observed for calculating disease activity score of 28 joints （DAS28）. At the same time, patients were classified according to TCM syndromes. The meteorological data were col- lected. The correlation between meteorological factors （temperature, air pressure, relative humidity and wind speed） and DAS28 was analyzed by bivariate linear correlation analysis. Results In 188 RA patients, the most common TCM syndrome was blockage of cold and damp （71 cases, 37.8% ） and it occurred mainly in winter. There is a sta- tistical significance in syndrome distribution difference between each season （ P 〈 0. 05 ）. Among meteorological fac- tors, temperature and wind speed had negative correlation with DAS28 （P 〈 0. 01 ）. Conclusion Blockage of cold and damp is the main syndrome of RA which mainly occurs in winter. When temperature and wind speed go down, disease activity of RA will go up on the contrary.
出处
《中医杂志》
CSCD
北大核心
2014年第22期1933-1936,共4页
Journal of Traditional Chinese Medicine
关键词
类风湿关节炎
气象因素
中医证候
疾病活动度
相关性分析
rheumatoid arthritis
meteorological factors
TCM syndrome
disease activity index
correlation analysis
