摘要
视网膜母细胞瘤（RB）动物模型研究的进展加快了对RB生物学特性及其治疗方案研究的步伐.目前主要有转基因模型和异种移植瘤模型两大类.RB转基因模型经历了从LH-β-Tag模型到选择性基因敲除模型的发展过程.RB异种移植瘤模型包括眼内移植瘤模型和皮下移植瘤模型.转基因模型和异种移植瘤模型各有其优缺点,二者的结合为进一步研究RB的发生发展机制以及探索更有效的诊断治疗方案奠定了基础.本文就RB动物模型的研究进展及其在评价治疗方案中的应用进行综述.
Advances in animal models of retinoblastoma have accelerated the research in understanding tumor biology and assessing therapeutic modalities.At present,there are two types of models：transgenic models and xenograft models.The transgenic models have experienced a developmental process from LH-β-Tag models to conditional gene knock-out models.The xenograft models included intraocular transplantation models and subcutaneous transplantation models.The two types of RB models both have their merits and drawbacks.The combination of genetic and xenograft models in retinoblastoma research has and will help to pave way for better understanding tumor progression and searching more effective diagnosis and treatment modalities.In this review,we summarized the recent research progress in animal models of retinoblastoma and their application in assessing therapeutic modalities.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2014年第10期793-797,共5页
Chinese Journal of Ophthalmology
