摘要
目的探讨癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、组织多肽特异性抗原(TPS)3项标志物联合检测在非小细胞肺癌(NSCLC)中的诊断价值。方法采用电化学发光法测定保定市第一中心医院90例肺癌患者(肺癌组)和86例健康体检者(对照组)的CEA、CYFRA21-1和TPS 3项标志物水平。结果肺癌组CEA、CYFRA21-1和TPS 3项指标均明显高于对照组(P<0.001)。CEA对肺癌诊断的敏感性为47.8%,特异性为92.0%;CYFRA21-1的敏感性为61.1%,特异性为93.6%;TPS的敏感性为88.9%,特异性为89.1%。3项指标联合检测则敏感性为100.0%,特异性为87.8%。结论 CEA、CYFRA21-1和TPS对NSCLC的诊断具有一定的价值,三者联合检测有明显的互补性,可以显著提高NSCLC的诊断率。
Objective To explore the diagnostic value of combined detection of carcinoembryonic antigen （CEA）,cy-tokeratin 19 fragment（CYFRA21-1）and tissue polypeptide specific antigen（TPS）in patients with non-small cell lung cancer.Methods The serum levels of CEA,CYFRA21-1 and TPS were determined by electrochemi-luminescence in 90 patients with non-small cell lung cancer （lung cancer group）and 86 health adults （control group）in Baoding First Cen-tral Hospital.Results The levels of CEA,CYFRA21-1 and TPS in lung cancer group were significantly higher than those in control group （P＆lt;0.01）.The sensitivity and specificity of CEA,CYFRA21-1 and TPS to lung cancer were 47.8% and 92%,61.1% and 93.6%,88.9% and 89.1%.The sensitivity and specificity of combined detection of the three markers was 100.0% and 87.8%.Conclusion There is certain diagnostic value of CEA,CYFRA21-1 and TPS in non-small cell lung cancer.and complementarity of combined detection of the three markers,which could significantly improve diagnostic rate of NSCLC.
出处
《中国实验诊断学》
2014年第10期1613-1615,共3页
Chinese Journal of Laboratory Diagnosis
