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腹腔镜与开腹胆囊切除术后凝血及纤溶系统的变化 被引量:6

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摘要 目的观察腹腔镜与开腹胆囊切除术后凝血与纤溶系统的变化。方法选择胆囊切除患者120例,其中行腹腔镜胆囊切除术60例(LC组),行开腹胆囊切除术60例(OC组)。两组均于术前72 h及术后24、72 h采集静脉血,检测活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原含量(FIB)、D-二聚体(D-D),术后2-5 d行双下肢静脉超声检查,计算深静脉血栓(DVT)发生率。结果两组术后24、72 h时PT、D-D、FIB均升高(P均〈0.05),LC组术后24 h时PT、D-D、FIB均高于OC组(P均〈0.05),OC组术后24、72 h FIB高于LC组(P均〈0.05);LC组术后24、72 h时APTT先降后升,均低于术前及OC组同时点(P均〈0.05);术后TT先升后降,术后24 h与术前比较,P〈0.05;OC组中APTT、TT术后变化不大(P均〉0.05)。LC组术后DVT发生率为13.3%,OC组为6.6%,P〈0.05。结论两种术式均会影响凝血与纤溶系统,而腹腔镜胆囊切除术更易引起DVT。
出处 《山东医药》 CAS 2014年第32期82-84,共3页 Shandong Medical Journal
基金 国家自然科学基金资助项目(81273952)
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