摘要
归纳总结骨髓间充质干细胞的诱导方法和现代应用情况,为骨髓间充质干细胞诱导分化成骨细胞的深人研究提供参考。通过查阅、整理有关骨髓间充质干细胞的文献资料,从骨髓间充质干细胞的生物特性与制备、诱导成骨细胞的方法、在组织工程骨中的应用、所面临的问题以及未来的研究方向等方面进行总结和分析。结果显示骨髓间充质干细胞具有多向分化潜能,体外可诱导分化为成骨细胞,采用组织工程学技术可在体外构建骨组织工程支架。基于骨髓间充质干细胞的特性,使其在创伤修复、细胞替代治疗、支持造血、基因治疗等方面的应用前景也相当广阔。有必要开展骨髓间充质干细胞成骨诱导分化机制的研究,为其诱导分化成骨细胞提供指导意义和借鉴价值。
The aim of this study was to summarize the processing induced osteogenic differentiation and modern applications of bone marrow mesenchymal stem cells so as to provide a reference for its further study. By referring to the relevant literatures, the processing research of bone marrow mesenchymal stem cells was summarized and analyzed. The review mainly focused on the biological characteristics of bone marrow mesenchymal stem cells, induced osteogenic differentiation, the application of tissue engineering bone, the problems of bone marrow mesenchymal stem cells at present and the research direction in the future. It has been revealed that bone marrow mesenchymal stem cells have the multi-potential of differentiation and can be induced to differentiate into osteogenic ex vivo. Bone marrow mesenchymal stem cells can be used for wound healing, cell replacement therapy, hematopoiesis and gene therapy due to their characteristics. Understanding the mechanisms of induction and differentiation will be of important value to the research method of differentiation of bone marrow stromal ceils into osteoblasts.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第19期228-231,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81273776)
山东省科技攻关计划项目(2010GCSF10278)
2012年度山东省自主创新重大计划项目(2012ZHZX1C0405)
山东中医药科技发展计划项目(2011-154)
山东省科技发展专项(2012G0021846)
关键词
骨髓间充质干细胞
成骨细胞
诱导分化
bone mesenchymal stem cells
osteoblast cells
osteogenic differentiation
