摘要
目的观察脑毒清颗粒对脑缺血再灌注损伤大鼠血清超氧化物歧化酶(SOD)、丙二醛(MDA)和超敏C反应蛋白(hs-CRP)含量的影响,探讨脑毒清颗粒对脑缺血再灌注损伤治疗的作用机制。方法应用线栓法复制脑缺血再灌注损伤大鼠模型(MCAO),2 h后抽取线栓对大鼠进行脑缺血再灌注,进行神经功能缺损程度评分,分别于12、24、48h 3个时间点观察大鼠血清SOD、MDA、hs-CRP含量的变化。结果与模型组比较,脑毒清组大鼠神经功能缺损评分明显下降,大鼠血清SOD含量增多,MDA含量减少,hs-CRP含量减少。结论脑毒清颗粒具有明显改善大鼠脑缺血再灌注损伤的作用,其机制与大鼠血清SOD、MDA及hs-CRP变化有关。
Objective： To observe the effect and mechanism of Naoduqing Granules on SOD,MDA and hs-CRP contents of cerebral ischemia-reperfusion injury rats model. Methods： Animal model of focal cerebral ischemia was established by using suture method in mature SD rats. Neurological severity scores as well as the activity of MDA, SOD, hs-CRP in brain tissue of cerebral ischemia after 12,24, and 48 hours were detected. Results： Com- pared with model group,level of SOD was increased and level of MDA and hs-CRP were decreased with signifi- cant statistical differences. Conclusion： Naoduqing Granules has obvious ameliorating effect on rats with focal cerebral ischemia,which is caused by reduction of SOD, MDA and hs-CRP contents.
出处
《中国中医急症》
2014年第9期1605-1606,1632,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
黑龙江省哈尔滨市青年科技创新人才研究专项资金项目(2010RFQYS084)
