摘要
目的 观察米索前列醇联合阿托品用于无痛人工流产术的临床效果.方法 选择2010年10月至2012年12月衡水市第五人民医院收治的宫内妊娠40～ 70 d要求无痛人工流产的孕妇800例,采用随机数字表法分为两组：观察组（400例）在实施无痛人流术前服用米索前列醇片,实施无痛人流术中用阿托品,其中孕6～8＋6周受术者236例,孕9～12周受术者164例;对照组（400）未行术前药物处理的常规人工流产术,其中孕6～8＋6周受术者225例,孕9～12周受术者175例.观察两组患者扩宫器、术中出血量、宫颈松弛、扩宫时间、出血量、人工流产综合征及不良反应的发生情况及两组术后的镇痛效果.结果 观察组孕6～8＋6周和孕9～12周的宫颈松弛有效率、扩宫时间、无痛率、出血量与对照组孕6～8＋6周和孕9～12周比较差异均有统计学意义（P＜0.05）.观察组宫缩良好,宫缩率为66.75％（267/400）,显著高于对照组的26.00％（104/400）（x2=16.018,P＜0.05）.观察组不全流产发生率为0.25％（1/400）,对照组发生率为0.5％（2/400）,两组比较差异无统计学意义（x2 =2.102,P ＞0.05）.两组患者均无子宫穿孔、漏吸、空吸及宫颈撕裂者.观察组发生不良反应发生率低于对照组（11.25％ vs43.5％）（P＜0.05）.结论 在无痛人工流产术中,米索前列醇能有效地软化宫颈,协同阿托品使宫颈肌肉松弛的同时降低人工流产综合征的发生率,并能减轻术后恶心、呕吐和腹痛的程度,有利于保证手术质量和安全性,可推广应用.
Objective To observe the clinical effect of misoprostol combined with atropine in painless artificialabortion.Methods From Oct.2010 to Dec.2012 in Hengshui Fifth Hospital 800 pregnant women with 40-70 d intrauterine pregnancy requiring for painless artificial abortion were selected and randomly divided into observation group（400 cases） who were given misoprostol before abortion and atropine during operation,including 236 cases of 6-8 ＋6 weeks pregnancy and 164 cases of 9-12 weeks pregnancy,and control group（400 cases） who received no drug treatment before operation,including 225 cases 6 weeks or 6-8 ＋6 weeks pregnancy and 175 cases of 9-12 weeks pregnancy.The uterus dilator,amount of intraoperative bleeding,ceical relaxation and dilation time,amount of bleeding,abortion syndrome and adverse reaction incidence,and the postoperative analgesic effects of the two groups were observed.Results The cervical relaxation rate,time,painless proportion,and bleeding amount of 6-8 ＋6 weeks and 9-12 weeks of the observation group were statistically significantly different from the control group（P 〈 0.05）.The contractions of the observation group was good,and the uterine contraction rate was 66.75% （267/400）,significantly higher than the control group＇s 26.00% （104/400） （x2 =16.018,P 〈 0.05）.The incomplete abortion rate of the observation group was 0.25% （1/400）,of the control group was 0.5% （2/400）,no significant difference between the two groups （x 2 =2.102,P 〉 0.05）.There were no uterine perforation,drain suction,suction and cervical laceration in either group.The adverse reaction of the observation group was lower than the control group（11.25% vs 43.5%）（P 〈 0.05）.Conclusion Misoprostol in painless artificial abortion,can effectivelysoften the cervix,and collaborative atropine can make the cervical muscle relaxed at the same time,reduce the incidence of induced abortion syndrome,degree of nausea,vomiting and abdominal pain after the operation,which is helpful to ensure the quality and safety of operation,thus can be applied.
出处
《医学综述》
2014年第18期3415-3417,共3页
Medical Recapitulate
基金
衡水市科学技术研究与发展计划
