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沙利度胺治疗消化系统肿瘤的研究进展 被引量:1

Research progress of thalidomide in the treatment of digestive tumors
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摘要 沙利度胺治疗实体肿瘤的作用机制是多方面的,主要是抑制实体肿瘤新生血管生成,协同激活T淋巴细胞,调节免疫抑制作用。目前有多项临床研究已经确定沙利度胺治疗晚期消化道肿瘤的治疗作用。本文就沙利度胺治疗消化系统恶性肿瘤的最新研究进展作一综述。 The mechanism of thalidomide is complex in the treatment of solid tumors,mainly including the inhibition of new solid tumor angiogenesis,synergistic activation of T-lymphocytes,immunosuppressive action.At present,clinical studies have demonstrated that thalidomide has a potential treatment effect on digestive tumor.In this paper,the new research progress of thalidomide in the treatment of digestive tumors is reviewed.
作者 高东 李玲
出处 《武警后勤学院学报(医学版)》 CAS 2014年第6期550-552,共3页 Journal of Logistics University of PAP(Medical Sciences)
关键词 沙利度胺 消化系统肿瘤 肿瘤治疗 Thalidomide Digestive tumor Tumor therapy
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  • 1要洁,冯奉仪,林晨,张雪燕,付明,梁萧,杨莹.吉西他滨耐药胰腺癌细胞系的耐药机制[J].中华肿瘤杂志,2005,27(12):721-726. 被引量:8
  • 2Bun'is HA 3rd, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol, 1997, 15:2403-2413.
  • 3Rachamalla R, Malamud S, Grossbard ML, et al. Phase I dose- finding study of biweekly irinotecan in combination with fixed doses of 5-fluorouracil/leucovorin, gemcitabine and cisplatin (G-FLIP) in patients with advanced pancreatic cancer or other solid tumors. Anticancer Drugs, 2004, 15:211-217.
  • 4Louvet C, Labianca R, Hanunel P, et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase I trial. J Clin Oncol, 2005,23:3509-3516.
  • 5Moore MJ, Goldstein D, Harnm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase m trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol, 2007, 25: 1960- 1966.
  • 6Boeck S, Wilkowski R, Bruns CJ, et al. Oral capecitabine in gemcitabine-pretreated patients with advanced pancreatic cancer. Oncology, 2007, 73:221-227.
  • 7Bohle AS, Kalthoff H. Molecular mechanisms of tumor metastasis and angiogenesis. Langenbecks Arch Surg, 1999, 384:133-140.
  • 8Du GJ, Lin HH, Xu QT, et al. Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis. Vascul Pharmacol, 2005, 43 : 112-119.
  • 9Gordon JN, Trebble TM, Ellis RD, et al. Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial. Gut, 2005, 54:540-545.
  • 10Pino MS, Mi|e|la M, Gehbter A, et al. Capecitabine and celecoxib as second-line treatment of advanced pancreatic and biliary tract cancers. Oncolo, 2009, 76:254-261.

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