2-氟-4-甲基吡啶-5-硼酸频那醇酯的合成工艺研究
Study on Process of Synthesis of 2-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)Pyridine
摘要
介绍了2-氟-4-甲基吡啶-5-硼酸频那醇酯的合成工艺。以2-氟-4-甲基-5-溴吡啶和异丙醇频那醇硼酸酯为原料,采用正丁基锂法经一步直接合成得到标题化合物,并经MS和1HNMR进行了结构表征。本合成路线操作方便,收率较高,适合工业化生产。收率为62。
An important intermediate of medicine drugs was realized and manufactured from 5-bromo-2-fluoro-4-methylpyridine via one step. The program is suitable for industrial production. The product yield was 62 %. And its structure was verified by MS and 1H NMR.
出处
《广东化工》
CAS
2014年第17期8-8,共1页
Guangdong Chemical Industry
基金
贵大自青基和字(2013)07号
关键词
2-氟-4-甲基吡啶-5-硼酸频那醇酯
2-氟-4-甲基-5-溴吡啶
异丙醇频那醇硼酸酯
合成
2-fluoro-4-methyl-5-（4,4,5,5-telxamethyl-1,3,2-dioxaborolan-2-yl）pyridine： 5-bromo-2-fluoro-4-methylpyridine： 2-isopropoxy-4,4,5,5-tetramethyl- 1,3,2-dioxaborolane
synthesis
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