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白介素13在支气管哮喘发病中的作用 被引量:4

Effect of IL-13 on Bronchial Asthma
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摘要 通过对支气管哮喘发病机制研究总结,对白介素13(IL-13)在支气管哮喘发病机制中的作用进行分析,特别是IL-13在免疫-炎症、气道重塑、基因遗传方面的作用进行阐述分析。 Through the study of the pathogenesis of bronchial asthma , the role of IL-13 on the pathogenesis of bronchial asthma was analyzed, especially the role of IL-13 on immune inflammation , airway remodeling and genetic inheritance was explored , to provide new implications for bronchial asthma.
出处 《黑龙江医学》 2014年第8期933-934,共2页 Heilongjiang Medical Journal
关键词 支气管哮喘 发病机制 IL-13 Bronchial asthma Pathogenesis IL - 13
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参考文献16

  • 1陆再英,钟南山.内科学[M].7版.北京:人民卫生出版社,2008:775.
  • 2徐勤枝,丁新民,李强,刘忠令.IL-13与支气管哮喘[J].国外医学(免疫学分册),2001,24(3):156-159. 被引量:16
  • 3Donaldson D D, Whitters M J, Fitz L J,et al. The murine IL -13 receptor a2: moleccular cloning characterization, and comparison with murine IL - 13 receptor cx [ J ]. J Immunol,1998,161 (5) :2317 - 2324.
  • 4Aman M J, Tayebi N, Obiri N I, et al. eDNA cloning and characterization of the human interleukin 13 receptor alpha chain[ J]. J Biol Chem, 1996,271:29265 - 29270.
  • 5Cho S J, Kang M J, Homer R J, et al. Role of early growth response - 1 (Egr - 1 ) in interleukin - 13 - induced inflammation and remodeling [ J ] . J Biol Chem, 2006,281 : 8161 - 8168.
  • 6Defrance T, Carayon P, Billian G, et al. Interleukin 13 is a B cell stimulating factor[ J ]. J Exp Med, 1994, 179 ( 1 ) : 135 - 143.
  • 7Li L, Xia Y, Nguyen A, et al. Effects of Th2 cytokines on ehemokine expression in the lung: IL - 13 protently induces eotaxin expression by airwayepithelial cells [ J ]. J Immunol, 1999,162 (5) :2477 - 2487.
  • 8刘永生,周发春.哮喘患者血清IL-13、TGF-β1、VEGF表达变化及与气道炎症、重塑的关系探讨[J].重庆医科大学学报,2012,37(10):880-883. 被引量:28
  • 9Christou H, Yoshida A, Arthur V, et al. Increased vascular endothelial growth factor production in the lungs of rats with hypoxia- induced pulmonary hypertension [ J ]. Am J Respir Cell Mol Biol, 1998,6 (18) : 768 - 776.
  • 10江德鹏,Victor P.Kolosov,Juliy M.Perelman,周向东.白介素13通过FOXA2调控气道上皮细胞粘液分泌[J].中国免疫学杂志,2011,27(2):99-102. 被引量:10

二级参考文献41

  • 1王立波.人类T_H细胞亚群与支气管哮喘[J].国外医学(免疫学分册),1995,18(1):21-23. 被引量:14
  • 2刘剑波,张珍祥,徐永健,邢丽华,张惠兰.糖皮质激素对IL-13诱导的小鼠肺组织黏蛋白基因Muc5ac表达的影响[J].中国免疫学杂志,2006,22(8):764-767. 被引量:1
  • 3中华医学会呼吸病学分会哮喘学组.哮喘诊治指南(2007年修订版).中华结核和呼吸杂志,2007,30(1):8-8.
  • 4Woodruff P G,Boushey H A,Dolganov G M et al.Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids[J].Proc Natl Acad Sci USA,2007;104(40):15858-15863.
  • 5Tesfaigzi Y.Regulation of mucous cell metaplasia in bronchial asthma[J].Curr Mol Med,2008;8(5):408-415.
  • 6Rogers D F.Physiology of airway mucus secretion and pathophysiology of hyper-secretion[J].Respir Care,2007;52(9):1134-1146.
  • 7Kuperman D A,Huang X,Koth L L et al.Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma[J].Nat Med,2002;8(8):885-889.
  • 8Jin J O,Song M G,Kim Y N et al.The mechanism of fucoidan-induced apoptosis in leukemic cells:involvement of ERK1/2,JNK,glutathione,and nitric oxide[J] Mol Carcinog,2010;49(8):771-782.
  • 9Shao M X,Nakanaga T,Nadel J A.Cigarette smoke induces MUC5AC mucin overproduction via tumou necrosis factor-alpha-converting enzyme in hman airway epithelial cells[J].Am J Physiol Lung Cell Mol Physiol,2004;287(2):L420-L427.
  • 10Fischer B M,Voynow J A.Neutrophil elastase induces MUC5AC gene expression in airway epithelial via a pathway involving reactive oxygen species[J].Am J Respir Cell Mol Biol,2002;26(4):447-252.

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