摘要
目的评价连续性肾脏替代治疗(CRRT)对重度急性胰腺炎(SAP)患者的治疗效果。方法计算机检索MEDLINE(1966—2013.9)、Embase(1974—2013.9)、中文万方数据库(1996—2013.9)、CNKI(1979—2013.9)、Cochrane图书馆临床对照试验资料库。手工检索已发表或未发表的相关文献,包括会议摘要等。由2名评价员独立对纳入的文献进行质量评价和数据提取,用RevMan5.2软件进行Meta分析。结果共纳入15项随机对照试验,共计652例患者。Meta分析结果显示CRRT治疗与传统治疗方法比较,可以明显降低血淀粉酶水平(WMD=-140.76,95%CI为-212.42^-69.11,P=0.000 1),清除炎症介质,降低APACHEⅡ评分(WMD=-2.97,95%CI-4.01^-1.93,P<0.001),有效提高存活率(RR=1.35,95%CI 1.19~1.52,P<0.001)。结论 CRRT治疗可有效提高SAP患者的存活率。
Objective To assess the effect of continuous renal replacement therapy （CRRT） on severe acute pancre-atitis （SAP）. Methods According to the collaborative search strategy, MEDLINE （1966-2013.9）, Embase（1974-2013.9）, Chinese Wanfang database（1996-2013.9）, CNKI（1979-2013.9） and the clinical control test database of Cochrane Library were searched.Published and unpublished literature and meeting summary were searched manually.Quality assessment and data extraction were conducted by two independent investigators. Meta-analysis was performed using RevMan 5.2. Results A total of 15 reports were identified which met the inclusion criteria, in which include data of 652 patients.Com-pared with control group, serum amylase decreased in CRRT group （WMD=-140.76, 95%CI was-212.42 to-69.11, P=0.000 1）. Mediators of inflammatory mediators were scavenged effectively and APACHEⅡscore decreased in CRRT group （WMD=-2.97, 95%CI was-4.01 to-1.93, P〈0.001）. The overall survival rate was significantly higher in CRRT group than that in control group （RR=1.35, 95%CI 1.19-1.52, P〈0.001）. Conclusion Continuous renal replacement therapy could ef-fectively improve the survival rate of patients with severe acute pancreatitis.
出处
《天津医药》
CAS
北大核心
2014年第8期834-839,共6页
Tianjin Medical Journal
