摘要
警戒素是近年来发现的一类能增强机体免疫功能的内源性物质,广泛存在于各种细胞内,帮助人体抵抗外界刺激.研究发现,在皮肤病中,多种警戒素表达异常,包括防御素、抗菌肽、嗜酸性粒细胞来源的神经毒素、部分高迁移率族蛋白等.不同警戒素在不同皮肤病中表达情况各异,作用不尽相同,包括抑制炎症、破坏免疫平衡、诱导细胞恶变、促进基质增生及纤维化过程等,这些异常可能是其发病机制,也可能是继发性的改变,已有通过调节警戒素作用的药物,希望能有助患者恢复健康.
Alarmins are a bunch of recently discovered endogenous substances which can enhance the immune function of organisms.These substances exist in various cells,helping the body to fight against external stimuli.There is an abnormal expression of alarmins,e.g,,defensins,cathelicidin,eosinophil-derived neurotoxin,some high-mobility group proteins,in many skin diseases.The expression and function profiles of alarmins vary in different skin diseases.They may suppress inflammation,break immune balance,induce malignant transformation of ceils,promot stromal hyperplasia and fibrosis,etc.The changes of alarmins may either be involved in the pathogenesis of diseases,or be just secondary reactions.There have been alarmintargeted drugs,which are expected to benefit the recovery of patients.
出处
《国际皮肤性病学杂志》
2014年第4期247-249,共3页
International Journal of Dermatology and Venereology
