摘要
目的:探讨针刺治疗卵巢早衰的临床疗效及作用机制。方法:采用前瞻性病例序列研究设计,共纳入30例患者,以调理冲任、疏肝宁神为法,针刺关元、大赫、太溪、太冲、百会等穴作为干预措施,每周治疗3次,3个月为一疗程,共治疗2个疗程。以患者的月经情况、雌二醇(E2)与促卵泡激素(FSH)水平、临床围绝经期症状积分为主要疗效指标。结果:治疗后总有效率为86.7%(26/30),痊愈率为16.7%(5/30);患者恢复规律月经周期率为16.7%(5/30),月经总回潮率为56.7%(17/30);治疗后E2明显升高[(45.41±18.09)pmol/L vs(59.07±24.21)pmol/L,P<0.05]、围绝经期症状积分明显降低(14.28±8.30vs 4.04±3.28,P<0.01);FSH治疗前后差异无统计学意义(P>0.05)。结论:针刺在改善卵巢早衰患者月经周期及围绝经期症状方面均有一定的疗效,其作用机制可能与升高E2水平有关。
Objective To explore the clinical efficacy and action mechanism of acupuncture for premature ovarian failure（POF）.Methods According to prospective cohort study design,30cases were included.Based on theory of regulating Chong and Conception Vessels as well as soothing the liver and calming the nerves,acupuncture at Guanyuan（CV 4）,Dahe（KI 12）,Taixi（KI 3）,Taichong（LR 3）,Baihui（GV 20）was applied,three times per week and 3months were considered as one session.Totally two sessions were performed.The menstruation condition,estradiol（E2）,follicle-stimulating hormone（FSH）and scores of the clinical perimenopausal symptoms were taken as treatment outcomes.Results The total effective rate was 86.7%（26/30）and the cured rate was 16.7%（5/30）.The recovery rate of menstruation was 16.7%（5/30）and the regain rate of menstruation was56.7%（17/30）.After the treatment,the level of E2was significantly increased from（45.41±18.09）pmol/L to（59.07±24.21）pmol/L（P〈0.05）,and the score of perimenopausal symptoms was obviously reduced from14.28±8.30to 4.04±3.28（P〈0.01）.However,no statistical differences could be seen in FSH before and after treatment（P〈0.05）.Conclusion Acupuncture has certain effect on improving menstruation and perimenopausal symptoms in POF patients,which is likely to be related with increasing the level of E2.
出处
《中国针灸》
CAS
CSCD
北大核心
2014年第7期653-656,共4页
Chinese Acupuncture & Moxibustion
关键词
卵巢早衰
闭经
针刺疗法
雌二醇
促卵泡激素
premature ovarian failure
acupuncture therapy
amenorrhea
estradiol
follicle-stimulating hormone
