摘要
目的探讨术后三维适形放疗(3DCRT)同步卡培他滨+奥沙利铂(XELOX)方案治疗胃癌的疗效。方法胃癌患者76例随机均分为两组,A组术后采用3DCRT同步XELOX方案治疗,B组采用XELOX方案治疗。比较3个月时的生活质量评分、3年生存率和不良反应。结果 A、B组治疗完成率分别为85.71%和86.84%(P>0.05)。A组生活质量评分良好率和较好率分别为39.47%和50.00%,均高于B组的21.05%和26.32%(P<0.05)。随访9-36个月。A组1年、2年和3年生存率分别为73.68%(28/38)、52.63%(20/38)和36.84%(14/38),均高于B组的44.74%(17/38)、26.32%(10/38)和15.79%(6/38)(P<0.05)。两组不良反应发生率相仿,主要为胃肠道反应、骨髓抑制、肝功能损伤及手指综合征。结论胃癌术后采用3DCRT复合同步XELOX方案治疗能提高患者生存质量及生存期,不良反应尚可耐受。
Objective To investigate the efficacy of three dimensional conformal radiotherapy（3DCRT）combined with concurrent capecitabine and oxaliplatin（XELOX）regimen for gastric cancer after operation.Methods Seventy-six patients with gastric cancer after operation were equally randomized into two groups of A（treated with 3DCRT and concurrent XELOX）and B（treated with3DCRT alone）.The quality score of life in the 3rd month,3-year survival rate and adverse reaction were compared.Results The completion rates of treatment for two groups were similar（85.71% vs.86.84%）（P〉0.05）.The rates of good and better living quality were 39.47%and 50.00%in group A,which were higher than 21.05%and 26.32%in group B（P〈0.05）.The patients were followed up for 9-36months.The 1-,2-and 3-year survival rates were 73.68%（28/38）,52.63%（20/38）and36.84%（14/38）in group A,which were higher than 44.74%（17/38）,26.32%（10/38）and 15.79%（6/38）in group B（P〈0.05）.The main adverse reactions were gastrointestinal reaction,bone marrow suppression,liver damage and finger syndrome,the incidences of which in two groups were similar.Conclusion The treatment with 3DCRT and concurrent XELOX regimen in the patients with gastric cancer after operation can improve the quality of life,prolong the survival with tolerable adverse reactions.
出处
《江苏医药》
CAS
北大核心
2014年第13期1536-1538,共3页
Jiangsu Medical Journal
关键词
胃癌
三维适形放疗
XELOX方案
Gastric cancer
Three dimensional conformal radiotherapy
XELOX regimen
