摘要
目的探讨乙型肝炎肝硬化患者血清白介素17(interleukin17,IL-17)、白介素23(interleukin23,IL-23)、C反应蛋白(C-reactive protein,CRP)水平的变化及其意义。方法收集10例健康体检者作为正常对照,40例慢性乙型肝炎,38例代偿期肝硬化,40例失代偿期肝硬化。应用酶联免疫分析法(ELISA)及免疫比浊法测定各组患者血清中IL-17、IL-23和CRP水平并进行比较。结果 1各组患者与正常对照组血清IL-17、IL-23和CRP水平差异均有统计学意义(P<0.05)。代偿期肝硬化组、失代偿期肝硬化组和慢性乙型肝炎组之间比较差异有统计学意义(P<0.05)。2乙型肝炎肝硬化患者血清IL-17和IL-23、CRP呈正相关。结论1乙型肝炎肝硬化患者血清IL-17水平远高于正常人,与公认的反应炎症状态的指标CRP呈正相关性,提示IL-17可能参与了乙型肝炎肝硬化的慢性炎症和肝纤维化;2IL-17和IL-23表达水平有密切相关性,IL-23可能通过诱导IL-17的产生而使后者在乙型肝炎肝硬化的发病中发挥作用。
Objective To observe the changes of and correlation between IL-17 and IL-23 for exploring the relation between IL-17,IL-23,immune anomaly and chronic inflammation in patients with HBV liver cirrhosis. Methods IL-17 and IL-23 in serum of 40 cases of decompensated liver cirrhosis,38 cases of compensatory liver cirrhosis,40 cases of chronic hepatitis B and 10 cases of healthy control were measured by sandwich ELISA. The levels of CRP were measured by immune turbidimetry. Results 1 Serum IL-l7,IL-23 and CRP in patients were much higher than those in normal group( P < 0. 05),and the expressions of IL-17,IL-23 and CRP in patients showed statistical significance among different groups( P < 0. 05). 2 IL-17 was positively correlated to IL-23( r = 0. 613,P < 0. 05) and CRP( r = 0. 551,P <0. 05). Conclusion 1 IL-17 in patients is much higher than that in normal people,and is positively correlated to CRP,the acknowledged marker of inflammation status,suggesting that IL-17 plays an important role in pathogenesis of chronic inflammation and liver fibrosis in patients with HBV liver cirrhosis and chronic HBV infection. 2IL-17 is positively correlated to IL-23,suggesting that IL-23 may play a critical role in the development of HBV liver cirrhosis through inducing the production of IL-17.
出处
《安徽医学》
2015年第1期34-36,共3页
Anhui Medical Journal
基金
四川省卫生厅科研课题项目资助(100074)
成都大学附属医院科研课题项目资助(201317)
