摘要
目的探讨重组组织型纤溶酶原激活剂(rt-PA)动脉溶栓联合丹红注射液对急性脑梗死(ACI)患者血清神经细胞因子和炎性因子水平的影响。方法选取2016年2月-2017年10月在安阳市第三人民医院神经内科接受治疗的ACI患者80例,根据乱数表法将其分为对照组(n=40)和观察组(n=40);对照组采用rt-PA动脉溶栓治疗,观察组采用rt-PA动脉溶栓联合丹红注射液进行治疗;比较2组患者的治疗效果、神经功能缺损程度(NFDS)评分、Barthel评分、神经元特异性烯醇化酶(NSE)、S-100β蛋白、白介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平,观察2组患者的不良反应发生率。结果观察组的有效率为82.50%(33/40),明显高于对照组的62.50%(25/40)(P<0.05);治疗24 h后、治疗7、14 d后2组患者的NFDS评分均低于治疗前,Barthel评分均高于治疗前(P<0.05),在治疗24 h后、治疗7、14 d后观察组的NFDS评分均低于对照组,Barthel评分均高于对照组(P<0.05);治疗14 d后2组患者血清中的NSE和S-100β水平均低于治疗前,且观察组患者血清中的NSE和S-100β水平均低于对照组(P<0.05);治疗14 d后2组患者血清中的IL-6、CRP、TNF-α水平低于治疗前,且观察组患者血清中的IL-6、CRP、TNF-α水平低于对照组(P<0.05);2组患者的不良反应发生率比较无明显差异(P>0.05)。结论 rt-PA动脉溶栓联合丹红注射液治疗可以显著改善ACI患者神经功能缺损程度和生活能力,降低血清中神经细胞因子和炎性因子水平,具有较好的临床疗效。
Objective To investigate the effect of recombinant tissue plasminogen activator (rt-PA) combined with Danhong injection on serum cytokines and inflammatory factor levels in patients with acute cerebral infarction (ACI).Methods 80 patients with ACI who were treated in the department of neurology of Anyang third people’s hospital from February 2016 to October 2017 were selected,the patients were divided into the control group (n=40) and the observation group (n=40) according to the random digital table method.The control group was treated with rt-PA artery thrombolytic therapy,the observation group was treated with rtPA thrombolytic thrombolysis combined with Danhong Injection.The therapeutic effect,neurological deficit score(NFDS),Barthel score,neuron specific enolase (NSE),S-100βprotein,interleukin-6 (IL-6),C reactive protein (CRP) and tumor necrosis factor-α (TNF-α) levels were compared between the two groups.The incidence of adverse reaction was compared between the two groups.Results The effective rate of the observation group was 82.50% (33/40),which was significantly higher than 62.50% (25/40) of the control group (P<0.05).The NFDS scores of the two groups after the treatment of 24 h,7,14 d were all lower than those before treatment,and the Barthel score was higher than that before treatment (P<0.05),the NFDS score of the observation group was lower than that of the control group,and the Barthel score was higher than that of the control group (P<0.05).The levels of NSE and S-100 beta in the two groups after the treatment of 14 d were all lower than those before treatment,and the levels of NSE and S-100βin the observation group were all lower than those in the control group (P<0.05).The levels of IL-6,CRP and TNF-αin the two groups after the treatment of 14 d were lower than those before treatment,and the levels of IL-6,CRP and TNF-αin the observation group were lower than those in the control group (P<0.05).There was no significant difference in the incidence of adverse reaction between the two groups (P>0.05).Conclusion rt-PA thrombolysis combined with Danhong injection could significantly improve the neurological deficit and living ability of patients with ACI,reduce serum levels of cytokines and inflammatory factors,and had good clinical efficacy.
作者
吕秋杰
石福宏
单康娜
井晶
Lv Qiujie;Shi Fuhong;Shan Kangna(Department of Neurology,The Third People's Hospital of Anyang ,Anyang Henan 455000)
出处
《卒中与神经疾病》
2018年第6期635-639,共5页
Stroke and Nervous Diseases
基金
2015年度河南省政府决策研究课题招标一般课题(151903110053)
