摘要
在生理状态下,多样化的肠道微生物组可增强宿主的防御能力;而在危重症状态下,肠道微生物群可出现低多样性、关键共生属低丰度,以及某一菌属过度生长的现象,这些表现被称为微生态紊乱。越来越多的证据表明,肠道微生物来源的成分可以进入全身循环系统并调节免疫稳态。对于危重症患者来说,肠道微生态紊乱的危害十分严重,可导致预后不佳。本文通过分析肠道菌群对维持危重症患者全身稳态的重要性,总结菌群干预措施的新证据,为进一步确定危重症患者菌群失调的原因和后果,以及制定更加合理的干预策略提供新的视角。
In physiological conditions, a diverse microbiota might enhance host defense.However,the gut microbiota of critically ill patients is characterized by lower diversity,lower abundances of key commensal genera,and overgrowth by one bacterial generation,a state known as dysbiosis.Increasing evidences indicate that microbiota-derived components can reach the systemic circulation from the gut and modulate immune homeostasis.Dysbiosis could have greater consequences for the critically ill patients and might contribute to poor outcome.In this review,we highlighted the crucial role of intestinal microbiota in systemic homeostasis in the critically ill patients and summarized emerging evidence in the field of microbiota-targeted therapies.This would provide new perspective for further establishing the causes and consequences of dysbiosis found in the critically ill patients as well as developing new strategies of intervention.
作者
徐若霆
谭楚红
尹恝
潘速跃
Xu Ruoting;Tan Chuhong;Yin Jia;Pan Suyue(Department of Neurology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2018年第11期1099-1102,共4页
Chinese Critical Care Medicine
基金
国家自然科学基金(81671171).
关键词
危重症
肠道菌群
益生元
益生菌
粪菌移植
短链脂肪酸
Critieal illness
Gastrointestinal mierobiome
Prebiotics
Probiotics
Fecal microbiota transplantation
Short-chain fatty acid
