摘要
应用抗血小板血清造成豚鼠血小板减少症动物模型 ,观察人重组白细胞介素 11(rHuIL 11)对豚鼠血小板减少症的治疗作用 ,结果显示rHuIL 112 0 0 ,10 0 ,5 0 μg·kg-1均可明显升高豚鼠的血小板计数 ,增加骨髓巨核细胞集落生成单位 (CFU Meg)细胞集落数 ,与生理盐水对照组比较有明显差异。说明rHuIL
Objective To observe the effect of recombinant human interleukin 11on the platelet counts and the CFU Meg of the marrow cell culture. Methods Thrombocytopenia models of guinea pigs were made by injecting subcutaneously anti platelet serum. Results 200, 100, and 50 μg·kg -1 of rHuIL 11 increased the CFU Meg of the marrow cell culture and the peripheral platelet, showing a significant difference from that of the control group (P<0.05). Conclusion rHuIL 11 has a significantly therapeutic effect on thrombocytopenia models induced by anti platelet serum in guinea pigs.
出处
《湖南医科大学学报》
CSCD
北大核心
2002年第1期19-20,共2页
Bulletin of Hunan Medical University
