摘要
目的 探讨放射性支架抑制血管内膜增生的可行性。方法 使用回旋中子加速器轰击不锈钢支架 ,使其产生并载带放射性核素59Fe、60 Co、58Co、57Co、51 Cr、54 Mn。将放射性支架植于兔髂动脉。应用血管造影、组织病理学及免疫组织化学分析观察放射性支架预防再狭窄的疗效。结果 血管造影示髂动脉通畅 ,未见辐射相关并发症 ;放射性支架组较非放射性支架组血管新生内膜面积明显减少 [(0 .37± 0 .14)和 (0 .81± 0 .10 )mm2 ,P <0 .0 1],狭窄面积百分比明显降低 [(6 .70± 2 .91) %和 (13.15± 1.40 ) % ,P <0 .0 1],平滑肌细胞增殖细胞核抗原 (PCNA)阳性率显著下降 [(2 .0 0± 1.5 8) %和 (10 .88± 6 .98) % ,P <0 0 5 ]。结论 放射性支架可抑制血管内膜增生 ,在兔损伤血管内放置可行。
Objective To update the clinical and experimental evaluation of the effects of radioactive stents on the prevention of intimal proliferation. Methods The stents were bombarded with suitably charged particles of adapted energy in the cyclotron to create a proper mixture of the radionuclides, 59Fe, 60Co, 58Co, 57Co, 51Cr, and 54Mn in them. The radioactive stents were implanted unilaterally in rabbit iliac arteries ;and at the sametime,non-radioactive stents were implanted in the contralateral iliac arteries of the same rabbits serving as controls. The effects of radioactive stents on prevention of restenosis were assessed by angiography, histomorphometry and immunocytochemistry. Results All the iliac arteries that had been implanted radioactive stents were clear on angiography and had no radiation complication during the 1～2 month follow-up. There was a significant reduction in neointimal area[(0.37±0.14) mm2 vs. (0.81±0.10) mm2, P <0.01], percent area stenosis[(6.70±2.91)% vs. (13.15±1.40)%, P <0.01]and PCNA immunoreactive rate[(2.00±1.58)% vs. (10.88±6.98)%, P <0.05] in the radioactive stents group compared with that in the control stents group. Conclusions Radioactive stents with an activity of 33.819～61.189 kBq could inhibit the intimal proliferation in the animal model. The radioactive stents implantation is feasible for prevention of intimal proliferation.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2001年第6期355-357,共3页
Chinese Journal of Nuclear Medicine
