摘要
目的 :研制泰硝滴耳液 ,治疗由需氧菌及厌氧菌引起的耳道感染。方法 :以甘油、水、乙醇为混合溶媒进行配制 ,采用双波长等吸收点法同时测定两主药含量 ,并考察了制剂的稳定性。结果 :甲硝唑和醋酸氯己定的平均回收率分别为99 34 % (RSD=0.57 %,n=6)、101 17 % (RSD=0.88 %,n=6)。结论 :该制剂配方合理 ,制备工艺简单 ,质控方法简便准确 ,稳定性良好。
OBJECTIVE:To prepare the compound chlorhexidine acetate ear drops for treating anaerobic and aerobic infections of antrum auris METHODS:The compound chlorhexidine acetate ear drops was prepared with mixed solvent of glycerin,alcohol and distilled water The contents of two main ingredients were determined by dual-wavelength isobestic point spectrophotometry and the stability of preparation was examined RESULTS:The average recovery of metronidazole was 99 34%(RSD=0 57%,n=6) and that of chlorhexidine acetate was 101 17%(RSD=0 88%,n=6) CONCLUSION:The new preparation is rational in formula,simple in quality control and good in stability and has good prospects in development
出处
《中国药房》
CAS
CSCD
2001年第7期403-404,共2页
China Pharmacy
关键词
醋酸氯已定
甲硝唑
滴耳液
双波长等吸收点法
chlorhexidine acetate
metronidazole
ear drops
dual-wavelength isobestic point spectrophotometry
