摘要
目的观察中风康胶囊治疗急性脑梗塞的临床疗效及对线栓法造成的大鼠局灶性脑缺血后再灌注损伤的治疗作用。方法采用双盲法随机对照观察,设中风康胶囊治疗组30例和尼莫地平对照组30例;动物实验时,建立线栓法引起大鼠局灶性脑缺血模型,在缺血后4h进行再灌注,可引起大鼠产生明显的行为障碍和局灶性脑梗塞,用中风康胶囊口服,并同尼莫地平片进行比较。结果治疗组总有效率93.33%,对照组总有效率66.67%(P<0.05),中风康组疗效优于尼莫地平组;治疗组治疗后血液流变学、血脂较治疗前和对照组治疗后明显下降(P<0.05)。实验研究证实,中风康胶囊对大鼠线栓法造成的局灶性脑缺血损伤具有明显的治疗作用。结论中风康胶囊治疗急性脑梗塞有较好的疗效。
To observe Clinical and experimental effects of Zhong fengkang capsule treating acute cerebral infarction.Methods:60 patients were randomly assigned to obseration group (Zhongfengkang group,taking Zhongfengkang capsule,n=30)and control group(Nimodipine group,taking Nimodipine PO,n=30).The animal expe-riences can be made partian cerebral infarction of rats.Results:Observation group,almost curing 16 cases (53.3%),singificantly improving 10 cases(33.3%),im-proving 2 cases (6.7%),the whole effective rate is 93.3%.Control group:almost curing 5 cass (16.7%),significantly improving 7 cases(23.3%),improving 8 cases(26.6%),the whole effective rate in 66.7%(P<0.05).the animal experi-ences indicated that Zhongfengkang capsule can improve the infarction range of partial cerebral ischemic syndrome.Conclusion:Zhongfengkang capsule has a good effect on treating acute cerebral infarction.
出处
《中国中医急症》
2001年第5期250-252,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
上海市卫生局中医药科研基金课题(No.9622)
关键词
中风康胶囊
脑梗塞
临床疗效
实验
中医药疗法
Zhongfengkang capsule,cerebral infarction,clinical effects,animal ex-periences
