摘要
基于环氧酶 2 (COX 2 ) /5 脂氧酶 (5 LOX)双重抑制剂的设计思想 ,设计合成了 1 6个 (E) 3 甲氧基 4 肉桂酰氧基苯乙烯侧链衍生物。其中 1 3个化合物未见文献报道。所有目标物的化学结构经元素分析和波谱确证。体内初步药理试验结果表明 。
Based on the design idea of cyclooxygenase(COX-2) /5 -lipoxygenase(5-LOX)dual inhibitors,16 compounds of(E)-3-methoxy-4-cin namoyloxy styrene side derivatives were designed and synthesized.Among them 13 t arget compounds had been unreported.The chemical structures of all the target co mpounds were determined by elementary analysis, 1H-NMR as well as IR,etc.P re liminary results of the pharmacological tests in vivo showed that some of th e compounds had significantly antiinflammatory activities on two animal models,t hat is,ear swelling induced by xylene in mice and paw edema induced by carrageen in in rats.
出处
《中国药物化学杂志》
CAS
CSCD
2001年第4期209-214,共6页
Chinese Journal of Medicinal Chemistry
