摘要
通过人群流行病学调查、整体动物长期测试、短期遗传毒理学实验,结合国外资料肯定了杀虫脒及其主要代谢产物对氯邻甲苯胺对人的致癌性。其致膀胱癌危险度分别是;生产厂包转工为22.1×10^(-5)、施药农民为6.2×10^(-5)、进食残留杀虫脒稻米15年者为1.05×10^(-5),明显高于我国膀胱癌的粗死亡率0.63×10^(-5),也高于国际认为可接受的致癌危险度1×10^(-5)。
The human carcinogenicity of a pesticide, Chlorodimeform and its main metabolite p-Chloro-o-Toluidine was defined by the evidences of epi-demiological investigation integrating with the results of long-term animal assays as well as short-term tests.Summing up of our work and reviewing materials were presented. Quantitative risk assessment was made on the basis of dose-response correlation equation and exposure assessment.The results are:risk of the packer-22.1 × 10-5;spraymen 6.2× 10-5;residents cosumming rice with residues for 0. 1ppm,1.05× 10-5.A11 of these figures are exceeded the background mortality of urinary bladder cancer in Chinese population. Uncertainties and remedies of the assessment, and regulatory action to cope with this hazard are discussed,
出处
《环境化学》
CAS
CSCD
北大核心
1991年第3期54-58,共5页
Environmental Chemistry
