摘要
目的 探讨性激素受体在胆囊癌中的表达。方法 采用免疫组织化学AvidinBiotinPeroxidaseComplex (ABC)方法对 10 6例胆囊癌和 6 1例胆囊良性病变石蜡切片标本进行雌激素、孕激素及雄激素受体检测。结果 胆囊癌中三种受体阳性率分别为 6 7%、5 7%、44 %。性激素受体阳性率与胆囊癌分化程度有密切关系。结论 性激素与胆囊癌发展关系密切。
Objective To study the expression of sex hormone receptors in human gallbladder cancer. Methods Using immunohistochemistry avidin biotin peroxidase complex(ABC) method, the expression of estrogen receptor (ER)、 progesterone receptor (PR) and androgen receptor (AR) was examined in paraffin embedded sections of gallbladder cancer in 106 cases and 61 benign controls.[WT5”HZ]Results [WT5”BZ]The positive expression rate of ER、 PR and AR in gallbladder cancer was 67%、57% and 44% respectively. The positive rates of sex hormone receptors had significant correlation with pathologic differentiation grade. [WT5”HZ]Conclusion [WT5”BZ]There was significant correlations between sex hormones and the development of gallbladder cancer. Sex hormones might be implicated in the therapy of gallbladder cancer.
出处
《中华普通外科杂志》
CSCD
北大核心
2001年第5期299-300,共2页
Chinese Journal of General Surgery
