摘要
采用阿霉素致微小病变肾病模型大鼠(静脉注射盐酸阿霉素7.5mg/kg造模)观察肾复康的药效。结果表明:肾复康能明显降低阿霉素致肾损伤模型大鼠的尿蛋白总量,血清胆固醇、肌酐、尿素氮含量,血清和肾皮质匀浆的MDA含量,还能明显增加血清总蛋白和白蛋白含量、血清和肾皮质匀浆的SOD活性。肝病理镜检结果表明肾复康对肾实质损伤有较好的保护作用。结论:肾复康对阿霉素致微小病变肾病有显著的疗效。
Adriamycin - induced nephropathy (AIN) model in rats (mainlining 7.5 mg/kg avoirdupois adiramycine) was adopted to explore the effect of Shenfukang (SFK) .The results showed that SFK could remarkably reduce the content of urine protein, cholesterol, creatinine and urinary nitrogen in serum, MDA in serum and renal cortex of AIN model rats. And SFK also could increase the content of album and golbu-lin in serum, the activities of SOD in serum and renal cortex of AIN model rats. Conclusion:SFK played an important role on AIN.
出处
《中药材》
CAS
CSCD
北大核心
2001年第2期116-120,共5页
Journal of Chinese Medicinal Materials
基金
国家中医药管理局重点课题(NO:95B133)
广东省中医药管理局课题(NO:B98027)
