摘要
微小RNA（microRNA，miRNA）是一类由18～25个核苷酸小分子组成的非编码单链小RNA。大量研究表明，miRNA在细胞增殖、凋亡和肿瘤形成等方面发挥重要作用，与多种肿瘤的发生、发展、侵袭、转移密切相关，近年有关miRNA与宫颈癌关系的研究日益增多。在宫颈癌中miRNA表达谱存在明显异常，提示其可能在宫颈癌的发生和发展中扮演重要角色，但关于miRNA在宫颈癌中表达异常的调控机制目前研究较少，仍有待进一步研究。现就宫颈癌中miRNA的异常表达及其可能的调控机制进行综述。
MicroRNA（miRNA） is a family of 18-25 nucleotide non-coding RNA. Accumulating evidence indicated that miRNA played an important role in regulating the cells,proliferation,apoptosis and tumorigenesis. miRNA may be closely associated with a variety of tumor occurrence,development,invasion and metastasis. Great concern has been raised regarding the correlation between cervical cancer and miRNA recently. The aberrant expressions of several miRNAs in cervical cancer were demonstrated to be involved in the occurrence and development of cervical cancer. However researches on the abnormal expression and regulation mechanism of the miRNA in cervical cancer were not much ,still need further research. Here is to discuss the relationship between miRNA and cervical cancer and the possible regulation mechanism of the abnormal expression of miRNA.
出处
《国际妇产科学杂志》
CAS
2014年第3期252-255,共4页
Journal of International Obstetrics and Gynecology
基金
山西省卫生厅科技攻关计划项目(20100108)
山西省卫生厅青年项目(201301015)
