摘要
目的探讨琥珀酸索利那新、盐酸坦索罗辛单用或联用治疗经尿道离子束刀前列腺切除术后膀胱过度活动症的临床效果。方法选取我院近年来收治的经尿道离子束刀前列腺切除术后膀胱过度活动症患者84例,采用随机数字表法分为A组、B组和C组,每组各28例,分别给予琥珀酸索利那新单用、盐酸坦索罗辛单用和两种药物联用,比较三组患者术后膀胱阵发性痉挛疼痛次数,膀胱痉挛持续时间,拔管后尿频、尿急改善情况,手术前后OABSS评分、IPSS评分及QOL评分等。结果术后第3天,A组、B组和C组膀胱阵发性痉挛疼痛次数分别为(1.20±0.23)次、(2.04±0.31)次、(0.85±0.19)次;膀胱痉挛持续时间分别为(0.19±0.05)h、(0.25±0.07)h、(0.14±0.04)h。C组术后第3天膀胱阵发性痉挛疼痛次数和膀胱痉挛持续时间显著优于A、B组,且A组患者各项指标优于B组,差异有统计学意义(P<0.05);A组、B组和C组拔管后第3天尿频频率分别为(6.43±2.02)次/24 h、(9.27±3.18)次/24 h、(4.15±1.56)次/24 h;A组、B组和C组拔管后尿急频率分别为(5.60±1.42)次/24 h、(8.15±1.68)次/24 h、(4.19±1.30)次/24 h;C组患者拔管后第1、3天尿频和尿急频率均显著优于A、B组,且A组患者各项指标优于B组,差异有统计学意义(P<0.05);C组患者术后OABSS评分、IPSS评分及QOL评分均显著优于A、B组,且A组患者各项指标优于B组,差异有统计学意义(P<0.05)。结论琥珀酸索利那新与盐酸坦索罗辛联用治疗可有效缓解行尿道离子束刀前列腺切除患者术后膀胱过度活动,提高生活质量,效果优于琥珀酸索利那新、盐酸坦索罗辛单用。
Objective To investigate the clinical efficacy of solifenacin and tamsulosin used alone or combined treatment for overactive bladder after transurethral prostate resection by ion beam knife. Methods 84 patients were randomly divided into 3 groups,group A（ 28 patients） with solifenacin used alone treatment,group B（ 28 patients） with tamsulosin used alone treatment and group C（ 28 patients） with solifenacin combined with tamsulosin treatment; and the postoperative bladder paroxysmal spasm pain frequency,duration of bladder spasm,situation improvment of frequency and urgency of urination after extubation,before and after operation OABSS score,IPSS score and QOL score of 3 groups were compared. Results On 3rd day after operation,the bladder paroxysmal spasm pain frequency of group A,group B and group C were separately（ 1. 20 ± 0. 23） times,（ 2. 04 ± 0. 31） times,（ 0. 85 ± 0. 19） times; The duration of bladder spasm were（ 0. 19 ± 0. 05） h,（ 0. 25 ± 0. 07） h,（ 0. 14 ± 0. 04） h respectively. The bladder paroxysmal spasm pain frequency and duration of bladder spasm on 3rd after operation of group C was significantly better than that of group A and group B,and the same index of group A was significantly better than that of group B（ P〈0. 05）. The urination frequency after extubation in 3 days of group A,group B and group C were（ 6. 43 ± 2. 02） times /24 h,（ 9. 27 ± 3. 18） times /24 h,（ 4. 15 ±1. 56） times /24 h; The urination urgency after extubation on 3rd of group A,group B and group C were（ 5. 60 ± 1. 42）times /24 h,（ 8. 15 ± 1. 68） times /24 h,（ 4. 19 ± 1. 30） times /24 h; The frequency and urgency of urination after extubation on 3rd of groups C was significantly better than that of group A and group B,and the same index of group A was significantly better than that of group B（ P〈0. 05）. The OABSS score,IPSS score and QOL score after operation of group C was significantly better than that of group A and group B,and the same index of group A was significantly better than that of group B（ P〈0. 05）. Conclusion Compared with solifenacin and tamsulosin used alone,solifenacin combined with tamsulosin in patients with transurethral prostate resection by ion beam knife can relieve overactive bladder and improve life quality.
出处
《实用药物与临床》
CAS
2014年第6期774-777,共4页
Practical Pharmacy and Clinical Remedies
