摘要
目的：观察吸入噻托溴铵联合沙美特罗替卡松对慢性阻塞性肺疾病急性加重期（ AECOPD）的临床疗效。方法将2010年1月-2013年1月入院的62例AECOPD患者随机分为实验组和对照组，实验组31例给予噻托溴铵联合沙美特罗替卡松治疗，对照组31例仅给予沙美特罗替卡松治疗。治疗前及治疗结束出院时分别检测两组的肺功能指标（ FEV1、FVC、FEV1/FVC）、血气分析（PO2、SaO2、PCO2）、6 min步行实验（6MWT），并记录住院时间，进行对比分析。结果两组经过治疗后均有明显疗效，未见明显不良反应；实验组在肺功能指标、血气分析、6MWT及住院时间方面均优于对照组（ P﹤0.05）。结论噻托溴铵联合沙美特罗替卡松治疗AECOPD疗效确切，具有较高临床应用价值。
Objective To explore the clinical curative effect of tiotropium bromide combined with salmeterol fluticasone propionate on patients with acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）. Methods 62 cases with AECOPD hospitalized from Jan. ,2010 to Jan. ,2013 were randomly divided into 2 groups：experiment group and control group,31 in each;salmeterol fluticasone propionate was applied to all the patients in the 2 groups,while tiotropium bromide was added to patients in experiment group;the pulmonary functions（ FEV1、FVC、FEV1/FVC）,blood gas（ PO2、SaO2、PCO2 ）were detected and 6-minute walk test（6-MWT）was performed before and after treatment,respectively,and the days of hospitalization were recorded;a contrast study was then made. Results The treatment in the 2 groups was effective and no obvious side effect occurred;experiment group was superior to control group in pulmonary function,blood gas,6-MWT and the days of hospitalization（P﹤0. 05）. Conclusions The treatment of tiotropium bromide combined with salmeterol fluticasone propionate is of definite curative effect on patients with AECOPD and is worthy of wider clinical application.
出处
《西南国防医药》
CAS
2014年第6期596-598,共3页
Medical Journal of National Defending Forces in Southwest China
