摘要
低氧诱导因子(hypoxia inducible factor,HIF)是细胞应对氧气水平降低时的主要调节因子,具有调控与细胞缺氧应激相关基因表达的作用。HIF是由1个不稳定的氧气浓度依赖的α亚基(HIF-α)和1个稳定的不受氧气调节持续表达的β亚基(HIF-β)组成的异源二聚体。人的序列同源性的α亚基有3种,包括HIF-1α、HIF-2α和HIF-3α。相对于HIF-1α和HIF-2α亚基,对HIF-3α亚基的研究还是相对匮乏的。HIF-3α被认为是HIF-1α和HIF-2α的负调控因子,由于其具有多种剪接变异体,因此HIF-3α参与多种生理功能。该综述对HIF-3α的结构,剪接变异体,表达调控及其各种生理功能进行了系统的阐述,并对今后的研究方向进行了展望。
Hypoxia-indueible factor （HIF） is an ilnportant tran- scription factor of the eellular response to hypoxia, which trans- activates a lnyriad of genes to active adaptive responses to hypoxia. HIF is a heterodilner eolnprising an unstable oxygen-labile α （HIF-α） subunil and a stable constitutively expressed β（HIF-β） subunit, in hulnan beings, there are three isoforlns of α subunit including HIF-lα, HIF-2α and HIF-3α. in contrast to the in- depth studies of HIF-Iα and HIF-2α, we have still poorly known about HiF-3α HIF-3α has been conventionslly regarded as a negative regulator of HIF-lα and HIF-2α. Hif＇ -3α gene is sub- jeet to extensive alternative spliced variants which have a broad physiologieul functions. This review systematieully discusses the HIF-3αstructure, spliced variants, expression and regulation process in response to hypoxia, and it also discusses the future direction of research of HIF-3α.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2014年第3期22-25,共4页
Chinese Pharmacological Bulletin
基金
国家科技部重大资助项目(No 2008ZXJ09014-010)
全军医药科研"十二五"重点项目(No BWS12J012)
全军医药科研"十二五"面上项目(No CWS11C231)
关键词
低氧诱导因子-3α
剪接变异体
负调控
基因表达
肺发育
脂肪细胞分化
身体耐力
脑膜瘤
hypoxia inducible factor-3α
spliced variants
neg-ative regulation
gene expression
lung development
adiposedifferentiation
physiological endurance
lneningiomas
