摘要
目的观察果糖二磷酸钠联合高压氧治疗颅脑损伤的效果和对患者血清中神经特异性烯醇化酶(neuron specific enolase,NSE)的影响。方法将82例颅脑损伤患者随机分为对照组和治疗组两组各41例,治疗组除予常规治疗外再予果糖二磷酸钠联合高压氧治疗,对照组给予常规治疗,比较两组治疗前后血清中神经特异性烯醇化酶变化情况,并观察两组治疗前后GCS评分及伤后6个月GOS评分改善情况。结果治疗组总有效率90.2%,对照组总有效率70.7%,差异有统计学意义(P<0.05);治疗组治疗后NSE水平较治疗前下降均比对照组更为明显(P<0.05)。结论果糖二磷酸钠联合高压氧治疗颅脑损伤患者的临床效果明显,并可明显降低颅脑损伤患者血清NSE水平,明显改善预后。
Objective To investigate the clinical effect of fructose sodium diphosphate （FDP） combined with hyperbar ic oxygen therapy in treating craniocerebral injury which was evaluated by serumal neuron specific enolase （NSE）. Methods All 82 patients diagnozed with craniocerebr injury were randomly divided into two groups： control group, which received routine treatment; Experiment group, which received additional FDP combined with hyperbaric oxygen therapy. The clinical outcome were evaluated by serumal NSE, Glasgow Coma Scale（GCS） pre and posttreatment as well as Clasgow Outcome Score（GOS） 6 months after injury. Results The total effective rate of experimental group and control group was 90.2% and 70.7% respectively（P〈0.05）. The decline of NSE after treatment was more obvious in ex periment group than that in control group （P〈0.05）. Conclusion FDP combined with hyperbaric oxygen therapy could significantly reduce serumal NSE and enhance the prognosis of routine treatment of craniocerebral injury.
出处
《中国现代医生》
2014年第17期55-58,61,共5页
China Modern Doctor
基金
浙江省中医药各类科技计划(2008YA025)
关键词
高压氧
果糖二磷酸钠
颅脑损伤
神经特异性烯醇化酶
Hyperbaric oxygen
Fructose sodium diphosphate
Traumatic brain injury
Neuron specific enolase
