摘要
目的探讨冠心病患者低密度脂蛋白颗粒大小及小而密低密度脂蛋白(sd-LDL)浓度所占百分比(浓度比)与冠状动脉病变严重程度的关系。方法连续收集冠状动脉造影检查证实的冠心病患者60例为冠心病组,健康体检者30例为对照组。Lipoprint脂蛋白分析仪对LDL颗粒大小及亚组分进行分类,并计算sd-LDL浓度比,探讨低密度脂蛋白颗粒大小及sd-LDL浓度比与冠状动脉病变严重程度的关系,采用Gensini积分法及病变支数评估冠状动脉病变严重程度。结果 (1)冠心病患者低密度脂蛋白颗粒平均直径小于对照组(265.0±4.2比267.9±3.9,P<0.05),而B型比例和sd-LDL浓度比高于对照组(43.3%比20.0%,15.36%±10.74%比9.57%±7.55%,P<0.05)。(2)Logistic回归分析结果显示,体质指数、sd-LDL与冠心病密切相关。(3)多支病变组低密度脂蛋白颗粒平均直径小于单支病变组(264.1±3.3比265.7±3.5,P<0.05),而sd-LDL浓度比高于单支病变组(16.80%±10.87%比11.50%±8.38%,P<0.05)。(4)低密度脂蛋白颗粒大小与Gensini积分呈负相关(r=-0.430,P<0.01),与甘油三酯呈负相关(r=-0.408,P<0.01)。结论小而密低密度脂蛋白与冠心病明显相关,低密度脂蛋白颗粒直径减小、sd-LDL浓度比增加与冠状动脉病变程度显著相关。
Aim To explore the relationship between the low density lipoprotein particle size,percent of small density low-density lipoprotein（ sd-LDL） and the coronary artery disease with its severity. Methods Our work includes 2 groups,coronary artery disease（ CAD） group（ n = 60）,consecutive patients with coronary angiography（ CAG） confirmed by diagnosis,and control group（ n = 30）,healthy control. The LDL sub-fraction was quantified by Lipoprint system and the low density lipoprotein particle size,percent of small density low-density lipoprotein and the coronary artery disease with its severity were studied. Results Compared with control group,CAD group had smaller low density lipoprotein particle（ 265. 0 ± 4. 2 vs 267. 9 ± 3. 9,P〈0. 05）,increased percent of type B and small density low-density lipoprotein（ 43. 3% vs 20. 0%,（ 15. 36% ± 10. 74% vs 9. 57% ± 7. 55%,P〈0. 05）. Multivariate Logisitic regression analysis presented that BMI and sd-LDL were the independent predictions for CAD. Single faction analysis variance indicated that compared with single diseased coronary branch,the patients with multivessel disease had smaller low density lipoprotein particle（ 264. 1 ± 3. 3 vs 265. 7 ± 3. 5,P〈0. 05）,higher percent of small density low-density lipoprotein（ 16. 80% ±10. 87% vs 11. 50% ±8. 38%,P〈0. 05）. The low density lipoprotein particle size was negatively related to Gensini scores（ r =- 0. 430,P〈0. 01） and TG（ r =- 0. 408,P〈0. 01）. Conclusion Sd-LDL is obviously related to CAD occurrence,and decreased low density lipoprotein particle size and increased percent of small density lowdensity lipoprotein are associated with CAD severity.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2014年第4期399-403,共5页
Chinese Journal of Arteriosclerosis
关键词
低密度脂蛋白颗粒
冠心病
冠状动脉病变程度
Low Density Lipoprotein Particle
Coronary Artery Disease
Degree of Coronary Stenosis
