摘要
目的探讨血清及尿液结缔组织生长因子(connective tissue growth factor,CTGF)在狼疮性肾炎(lupus nephritis,LN)患者早期诊断中的临床意义。方法 100例LN患者根据尿中微量白蛋白(mAlb)水平分为Ⅰ组、Ⅱ组、Ⅲ组,另外选取40例健康体检者作为对照组,测定其SCr、BUN、血清及尿液CTGF水平,并分析血清及尿液CTGF水平与mAlb的关系。结果四组(狼疮性肾炎各组和对照组)的血清及尿液CTGF水平之间相比较存在明显的统计学意义(F值分别为175.235及156.871,P<0.05),狼疮性肾炎各组的血清及尿液CTGF水平与正常对照组比较均明显升高,Ⅰ组血清及尿液CTGF水平开始升高,Ⅱ组及Ⅲ组尿CTGF显著高于Ⅰ组,Ⅲ组尿CTGF显著高于Ⅱ组。狼疮性肾炎各组的血清及尿液CTGF水平与mAlb呈显著正相关(相关系数分别为r=0.715,P<0.05;r=0.456,P<0.05)。结论血清及尿液CTGF在狼疮性肾炎发生发展中可能起到重要作用,检测血清及尿液CTGF水平对于LN患者的早期诊断具有重要意义。
Objective To explore the clinical significance of serum and urine connective tissue growth factor（ CTGF） in early diagnosis of patients with lupus nephritis（ lupus nephritis,LN）. Methods 100 patients with LN and 40 of normal control subjects were selected. The LN patients were divided into three groups according to the levels of urine albumin（ uAlb） ： Ⅰgroup（ clinical albuminuria stage,mAlb ≥200 mg / L）,Ⅱgroup（ microalbuminuria stage,mAlb20 ~ 200 mg / L）,Ⅲ group（ normalalbuminuria stage,mAlb≤20 mg / L）. The levels of serum and urine CTGF were measured by ELISA. Results There were significant statistical differences in levels of serum and urine CTGF among the four groups（ F value were 175. 235,156. 871 respectively,P value were both 0. 05）. Compared with the normal control,levels of serum and urine CTGF in LN was significantly high; Compared with Ⅲ group,levels of serum and urine CTGF in ⅡandⅠgroups were significantly high. Levels of serum and urine CTGF in Ⅲ group were higher than those in Ⅱgroup. Levels of serum and urine CTGF was positively correlated with uAlb in LN patients（ r = 0. 715,P〈0. 05; r = 0. 456,P〈0. 05）. Conclusion Levels of serum and urine CTGF may play an important role in the beginning and development with lupus nephritis,detection of serum and urinary CTGF is of great significance for the early diagnosis of LN patients.
出处
《内蒙古医学杂志》
2014年第4期396-399,共4页
Inner Mongolia Medical Journal
基金
内蒙古自治区卫生厅科研课题(20081304)
关键词
结缔组织生长因子
狼疮性肾炎
系统性红斑狼疮
connective tissue growth factor lupus nephritis systemic lupus erythematosus
