摘要
目的:研究荜澄茄不同极性提取物的抗炎镇痛利胆作用。方法:通过小鼠甩尾实验测定甩尾潜伏期以观察荜澄茄不同极性提取物的镇痛作用;通过小鼠耳廓肿胀实验测定耳廓肿胀度以观察荜澄茄不同极性提取物的抗炎作用;通过大鼠、小鼠利胆实验测定胆汁量以观察荜澄茄不同极性提取物的利胆作用。结果:1.6、0.8 g/kg荜澄茄醚提物,2.4、1.2 g/kg荜澄茄醇提物,4.0、2.0 g/kg荜澄茄水提物,3.6、1.8 g/kg荜澄茄混合物能明显延长小鼠甩尾潜伏期;1.6、0.8 g/kg荜澄茄醚提物,2.4 g/kg荜澄茄醇提物,1.8g/kg荜澄茄混合物能明显减少小鼠耳廓肿胀度;1.20 g/kg荜澄茄醚提物、1.70 g/kg荜澄茄醇提物、2.80 g/kg荜澄茄水提物、2.55 g/kg荜澄茄混合物能明显增加大鼠1、3 h胆汁分泌量;1.20 g/kg荜澄茄醚提物、1.70 g/kg荜澄茄醇提物、2.55 g/kg荜澄茄混合物能明显增加大鼠2 h胆汁分泌量;1.20 g/kg荜澄茄醚提物、1.70 g/kg荜澄茄醇提物能明显增加大鼠5 h胆汁分泌量;1.20 g/kg荜澄茄醚提物能明显增加大鼠4、6 h胆汁分泌量。1.6 g/kg荜澄茄醚提物、2.4 g/kg荜澄茄醇提物、4.0 g/kg荜澄茄水提物、3.6 g/kg荜澄茄混合物能明显增加小鼠胆汁分泌量。结论:荜澄茄不同极性提取物具有抗炎镇痛利胆作用,有助于消除胆道炎症和症状,其中荜澄茄醚提物作用较强。
OBJECTIVE： To observe the cholagogic, analgesic and anti-inflammatory effects of various polar extracts of List- sea cubeba. METHODS： The swinging tail test and ear swelling test were adopted to observe the analgesic and anti-inflammatory of various polar extracts of L. cubeba on mice, respectively. The cholagogic test was used to determined the amount of bile secre- tion in rats and mice so as to observe cholagogic effect of various polar extracts of L. cubeba. RESULTS： 1.6, 0.8 g/kg ether ex- tracts of L, cubeba, 2.4, 1.2 g/kg ethanol extracts of L. cubeba, 4.0, 2.0 g/kg water extracts of L. cubeba and 3.6, 1.8 g/kg L. cu- beba mixture could prolong incubation of swinging tail; 1.6, 0.8 g/kg ether extracts of L. cubeba, 2.4 g/kg ethanol extracts of L. cu- beba, 1.8 g/kg L. cubeba mixture could reduce ear swelling; 1.2 g/kg ether extracts of L. cubeba, 1.7 g/kg ethanol extracts of L. cu- beba, 2.8 water extracts of L. cubeba and 2.55 g/kg L. cubeba mixture could increase the bile secretion of rats within I and 3 h and that of mice significantly. 1.2 g/kg ether extracts of L. cubeba, 1.7 g/kg ethanol extracts of L. cubeba and 2.55 g/kg L. cubeba mix- ture could increase the bile secretion of rats within 2 h. 1.2 g/kg ether extracts of L. cubeba, 1.7 g/kg ethanol extracts of L. cubeba could increase the bile secretion of rats within 5 h.l.2 g/kg ether extracts of L. cubeba could increase the bile secretion of rats with- in 4 and 6 h. 1.6 g/kg ether extracts of L. cubeba, 2.4 g/kg ethanol extracts of L. cubeba, 4.0 water extracts of L. cubeba and 3.6 g/ kg L. cubeba mixture could increase the bile secretion of mice.CONCLUSIONS： Various polar extracts of L. cubeba have cholagog- ic, analgesic and anti-inflammatory effects, which help to eliminate the inflammation of biliary passage and the symptoms. The ef- fects of ether extracts of L. cubeba are comparatively stronger.
出处
《中国药房》
CAS
CSCD
2014年第19期1744-1746,共3页
China Pharmacy
基金
陕西省中医药管理局科研项目(No.2007-63)
关键词
荜澄茄提取物
抗炎
镇痛
利胆
实验研究
Listsea cubeba extracts
Anti-inflammatory
Analgesic
Cholagogic
Experimental study
