摘要
目的：了解西安市健康人群麻疹抗体水平,评价人群麻疹疫苗免疫状况,为制定免疫策略和防治措施提供科学依据.方法：于2009年在西安市3个区县采用分层随机抽查0～40岁健康人群860名,分成7个年龄组,采用酶联免疫吸附试验（ELISA）方法进行麻疹IgG抗体水平检测.结果：被监测的860名健康人群中,843人麻疹IgG抗体为阳性,阳性率98.02％,抗体几何平均浓度（GMC）值为4 837.19 U/ml;麻疹抗体达保护水平的有718人,保护率83.19％,各年龄组之间阳性率、保护率经x2检验差异均有统计学意义（x阳^2=18.057,P=0.006;x保^2=30.510,P=0.000 0）,小于1岁和大于15岁以上人群保护率相对免疫人群较低,结论：西安市健康人群麻疹抗体水平较高,基本形成了预防麻疹的免疫屏障,对控制麻疹的发病起到了积极的作用,应对重点人群实行麻疹疫苗加强免疫.
Objective ： To know the measles antibody levels among healthy population in Xi＇ an city and to evaluate the immuni- zation status of measles vaccine, then to provide scientific basis for making immunization strategies and preventive measures. Methods ： In 2009, according 7 kinds of age group, 860 healthy persons ranged from 0 to 40 years old were selected by stratified random sampling method from 3 districts in Xi＇ an city. ELISA method was adopted to test measles antibody levels. Results ： Among 860 healthy persons there were 843 persons having positive antibody （the positive rate was 98.02% ）. The measles antibody GMC was 4 837.19 U/ml. The antibody levels of 718 persons reached to the protective level （the protective rate was 83.19% ）. There was significant difference among all age groups in the positive rates and the protective rates （ X2 = 18. 057, P = 0. 006 ; X2 = 30.510, P 〈 0. 001 ）. Compared to the immunized age groups, the population who were lower than 1 year old and who were more than 15 years old had the lower positive rate. Conclusion： The healthy population in Xi＇ an city has a high measles antibody level and basically formed the immunological barri- er to prevent measles, which can make a positive effect on controlling measles. Measles vaccine supplementary immunization should be conducted for the key groups.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2014年第4期516-519,共4页
Chinese Journal of Immunology
关键词
麻疹
抗体
监测
分析
Measles
Antibody
Monitor
Analysis
